PMID- 28318664
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20181113
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 241
DP  - 2017 Aug 15
TI  - Risk assessment of patients with clinical manifestations of cardiac sarcoidosis 
      with positron emission tomography and magnetic resonance imaging.
PG  - 457-462
LID - S0167-5273(16)34635-6 [pii]
LID - 10.1016/j.ijcard.2017.03.033 [doi]
AB  - BACKGROUND: Prior studies have shown that late gadolinium enhancement (LGE) on 
      cardiac magnetic resonance (CMR) and fluorodeoxyglucose (FDG) positron emission 
      tomography (PET) confer incremental risk assessment in patients with cardiac 
      sarcoidosis (CS). However, the incremental prognostic value of the combined use 
      of LGE and FDG compared to either test alone has not been investigated, and this 
      is the aim of the present study. METHODS: Retrospective observational study of 56 
      symptomatic patients with high clinical suspicion for CS who underwent LGE-CMR 
      and FDG-PET and were followed for the occurrence of death and/or malignant 
      ventricular arrhythmias (VA). RESULTS: The combination of PET and CMR yielded the 
      following groups: 1) LGE-negative/normal-PET (n=20), 2) LGE-positive/abnormal-FDG 
      (n=20), and 3) LGE-positive/normal FDG (n=16). After a median follow-up of 
      2.6years (IQR 1.2-4.1), 16 patients had events (7 deaths, 10 VA). All, but 1, 
      events occurred in patients with LGE. LGE-positive/abnormal-FDG (7 events, HR 
      10.1 [95% CI 1.2-84]; P=0.03) and LGE-positive/normal-FDG (8 events, HR 13.3 
      [1.7-107]; P=0.015) patients had comparable risk of events compared to the 
      reference LGE-negative/normal-PET group. In adjusted Cox-regression analysis, 
      presence of LGE (HR 18.1 [1.8-178]; P=0.013) was the only independent predictor 
      of events. CONCLUSION: CS patients with LGE alone or in association with FDG were 
      at similar risk of future events, which suggests that outcomes may be driven by 
      the presence of LGE (myocardial fibrosis) and not FDG (inflammation).
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Bravo, Paco E
AU  - Bravo PE
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States; Noninvasive Cardiovascular Imaging Program, Department of 
      Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 
      United States. Electronic address: pbravo@bwh.harvard.edu.
FAU - Raghu, Ganesh
AU  - Raghu G
AD  - Division of Pulmonary and Critical Care Medicine, University of Washington School 
      of Medicine, Seattle, WA, United States.
FAU - Rosenthal, David G
AU  - Rosenthal DG
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      United States.
FAU - Elman, Shana
AU  - Elman S
AD  - Department of Radiology, University of Washington School of Medicine, Seattle, 
      WA, United States.
FAU - Petek, Bradley J
AU  - Petek BJ
AD  - University of Washington School of Medicine, Seattle, WA, United States.
FAU - Soine, Laurie A
AU  - Soine LA
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States; Department of Radiology, University of Washington School of 
      Medicine, Seattle, WA, United States.
FAU - Maki, Jeffrey H
AU  - Maki JH
AD  - Department of Radiology, University of Washington School of Medicine, Seattle, 
      WA, United States.
FAU - Branch, Kelley R
AU  - Branch KR
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States.
FAU - Masri, Sofia C
AU  - Masri SC
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States.
FAU - Patton, Kristen K
AU  - Patton KK
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States.
FAU - Caldwell, James H
AU  - Caldwell JH
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States; Department of Radiology, University of Washington School of 
      Medicine, Seattle, WA, United States.
FAU - Krieger, Eric V
AU  - Krieger EV
AD  - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 
      United States.
LA  - eng
GR  - T32 HL094301/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
DEP - 20170310
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography/*methods
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sarcoidosis/*diagnostic imaging/epidemiology
PMC - PMC5469686
MID - NIHMS861061
COIS- Conflict of interest: None
EDAT- 2017/03/21 06:00
MHDA- 2018/03/22 06:00
PMCR- 2018/08/15
CRDT- 2017/03/21 06:00
PHST- 2016/12/18 00:00 [received]
PHST- 2017/02/17 00:00 [revised]
PHST- 2017/03/07 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/03/21 06:00 [entrez]
PHST- 2018/08/15 00:00 [pmc-release]
AID - S0167-5273(16)34635-6 [pii]
AID - 10.1016/j.ijcard.2017.03.033 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Aug 15;241:457-462. doi: 10.1016/j.ijcard.2017.03.033. Epub 
      2017 Mar 10.