PMID- 28319270
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180705
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Linking)
VI  - 49
IP  - 4
DP  - 2017 Apr
TI  - Evaluation of a transparent perfluorodecalin-infused patch as an adjunct to 
      laser-assisted tattoo removal: A pivotal trial.
PG  - 335-340
LID - 10.1002/lsm.22659 [doi]
AB  - BACKGROUND AND OBJECTIVE: Laser-assisted treatment of tattoos is well recognized 
      to produce opaque epidermal whitening that prevents multiple sequential passes 
      during a single treatment session. The amount of epidermal whitening produced in 
      association with the procedure can be minimized by topical application of 
      perfluorodecalin (PFD), which is an optical clearing agent. This pivotal trial 
      assessed the ability of a transparent PFD-infused patch used in conjunction with 
      a Q-switched nanosecond laser in the treatment of tattoos to permit multiple 
      laser passes during a single 5 minute treatment session in comparison to the 
      number of passes that could be completed using conventional treatment of the 
      tattoo with the laser alone. STUDY DESIGN: Thirty subjects (mean age 37 years; 14 
      males) with predominantly dark blue or black tattoos were enrolled in a 
      split-tattoo trial. One half of each tattoo was treated conventionally, whereas 
      the other half was treated through the PFD patch. Treatments were performed using 
      a nanosecond Q-switched 755-nm Alexandrite laser. The number of treatments 
      performed in a 5-minute time period was quantified for each side of the tattoo 
      (primary effectiveness outcome). Patient-reported pain scores and adverse events 
      (AEs) were also evaluated. RESULTS: Significantly more laser passes could be made 
      on average using the PFD patch compared with treatment using the laser alone (3.7 
      passes vs. 1.4 passes; P < 0.001). AEs were limited to those expected during 
      laser removal of tattoos. The proportions of subjects with transient edema and 
      erythema were lower in the PFD patch treatment group (36.7% vs. 63.3% and 33.3% 
      vs. 70.0%, respectively); all AEs were transient and resolved quickly. No patient 
      in either group exhibited dyschromia (hypo- or hyperpigmentation) in the 
      treatment area at the 1-month post treatment visit. Additionally, when surveyed 
      at the 1-month follow-up visit, all subjects (30/30) preferred to continue 
      laser-assisted tattoo removal with the PFD patch. CONCLUSION: An average of 3.7 
      laser passes were made in a defined 5-minute treatment session when using the 
      transparent PFD-infused patch, which is significantly more than was possible with 
      the laser alone (average of 1.4 passes). Use of the PFD patch was associated with 
      improved tolerability compared with conventional treatment, with subjects 
      experiencing fewer and less severe AEs related to epidermal injury. Lasers Surg. 
      Med. 49:335-340, 2017. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Biesman, Brian S
AU  - Biesman BS
AD  - The Practice of Brian S. Biesman, M.D., Nashville, Tennessee.
FAU - Costner, Cara
AU  - Costner C
AD  - The Practice of Brian S. Biesman, M.D., Nashville, Tennessee.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20170320
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 0 (Fluorocarbons)
RN  - 54A06VV62N (perfluorodecalin)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adult
MH  - Epidermis/radiation effects
MH  - Female
MH  - Fluorocarbons/*administration & dosage
MH  - Humans
MH  - Laser Therapy/adverse effects/*methods
MH  - Lasers, Solid-State/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Scattering, Radiation
MH  - *Tattooing
MH  - Transdermal Patch
MH  - Young Adult
OTO - NOTNLM
OT  - PFD
OT  - epidermal protection
OT  - laser tattoo removal
OT  - optical clearing
OT  - patch
OT  - perfluorodecalin
OT  - skin
EDAT- 2017/03/21 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/03/21 06:00
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/03/21 06:00 [entrez]
AID - 10.1002/lsm.22659 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2017 Apr;49(4):335-340. doi: 10.1002/lsm.22659. Epub 2017 Mar 
      20.