PMID- 28320272
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20180816
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 82
IP  - 3
DP  - 2017 Mar
TI  - Neurotrophic Factors (BDNF and GDNF) and the Serotonergic System of the Brain.
PG  - 308-317
LID - 10.1134/S0006297917030099 [doi]
AB  - Neurotrophic factors play a key role in development, differentiation, 
      synaptogenesis, and survival of neurons in the brain as well as in the process of 
      their adaptation to external influences. The serotonergic (5-HT) system is 
      another major factor in the development and neuroplasticity of the brain. In the 
      present review, the results of our own research as well as data provided in the 
      corresponding literature on the interaction of brain-derived neurotrophic factor 
      (BDNF) and glial cell line-derived neurotrophic factor (GDNF) with the 
      5-HT-system of the brain are considered. Attention is given to comparison of BDNF 
      and GDNF, the latter belonging to a different family of neurotrophic factors and 
      being mainly considered as a dopaminergic system controller. Data cited in this 
      review show that: (i) BDNF and GDNF interact with the 5-HT-system of the brain 
      through feedback mechanisms engaged in autoregulation of the complex involving 
      5-HT-system and neurotrophic factors; (ii) GDNF, as well as BDNF, stimulates the 
      growth of 5-HT neurons and affects the expression of key genes of the brain 
      5-HT-system - those coding tryptophan hydroxylase-2 and 5-HT(1A) and 5-HT(2A) 
      receptors. In turn, 5-HT affects the expression of genes that control BDNF and 
      GDNF in brain structures; (iii) the difference between BDNF and GDNF is 
      manifested in different levels and relative distribution of expression of these 
      factors in brain structures (BDNF expression is highest in hippocampus and 
      cortex, GDNF expression in the striatum), in varying reaction of 5-HT(2A) 
      receptors on BDNF and GDNF administration, and in different effects on certain 
      types of behavior.
FAU - Popova, N K
AU  - Popova NK
AD  - Federal Research Center Institute of Cytology and Genetics, Siberian Branch of 
      the Russian Academy of Sciences, Novosibirsk, 630090, Russia. 
      npopova@bionet.nsc.ru.
FAU - Ilchibaeva, T V
AU  - Ilchibaeva TV
FAU - Naumenko, V S
AU  - Naumenko VS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Receptor, Serotonin, 5-HT2A/metabolism
MH  - Serotonergic Neurons/metabolism
MH  - Serotonin/*metabolism
EDAT- 2017/03/23 06:00
MHDA- 2017/03/23 06:01
CRDT- 2017/03/22 06:00
PHST- 2017/03/22 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/03/23 06:01 [medline]
AID - BCM82030449 [pii]
AID - 10.1134/S0006297917030099 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2017 Mar;82(3):308-317. doi: 10.1134/S0006297917030099.