PMID- 28320276 OWN - NLM STAT- MEDLINE DCOM- 20170322 LR - 20170322 IS - 1608-3040 (Electronic) IS - 0006-2979 (Linking) VI - 82 IP - 3 DP - 2017 Mar TI - Effects of Short-Term Exposure to Lithium on Antiapoptotic Bcl-xL Protein Expression in Cortex and Hippocampus of Rats after Acute Stress. PG - 345-350 LID - 10.1134/S0006297917030130 [doi] AB - The antiapoptotic protein Bcl-xL is involved in development of neurobiological resilience to stress; hence, the possibility of use of psychotropic drugs to increase its expression in brain in response to stress is of considerable interest. Lithium is a neurotropic drug widely used in psychiatry. In work, we studied effects of lithium administration (for 2 or 7 days) on the expression of Bcl-xL mRNA and protein in the hippocampi and cortices of rats subjected to stress that induced depression-like behavior in the animals. In contrast to the brain-derived neurotrophic factor (BDNF), whose expression decreased in the hippocampus in response to acute stress, stress increased the level of Bcl-xL mRNA in the hippocampus, but decreased it in the frontal cortex. Treatment of stressed animals with lithium for 2 or 7 days increased Bcl-xL protein levels 1.5-fold in the hippocampus, but it decreased them in the cortex. Therefore, Bcl-xL expression in the brain can be modulated by both stress and psychotropic drugs, and the effects of these factors are brain region-specific: both stress exposure and lithium administration activated Bcl-xL expression in the hippocampus and suppressed it in the frontal cortex. The activation of Bcl-xL expression in the hippocampus by lithium, demonstrated for the first time in this study, suggests an important role of this protein in the therapeutic effects of lithium in the treatment of stress-induced psychoemotional disorders. FAU - Dygalo, N N AU - Dygalo NN AD - Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. FAU - Bannova, A V AU - Bannova AV FAU - Sukhareva, E V AU - Sukhareva EV FAU - Shishkina, G T AU - Shishkina GT FAU - Ayriyants, K A AU - Ayriyants KA FAU - Kalinina, T S AU - Kalinina TS LA - eng PT - Journal Article PL - United States TA - Biochemistry (Mosc) JT - Biochemistry. Biokhimiia JID - 0376536 RN - 0 (Bcl2l1 protein, rat) RN - 0 (bcl-X Protein) RN - 9FN79X2M3F (Lithium) RN - G4962QA067 (Lithium Chloride) SB - IM MH - Acute Disease MH - Animals MH - Frontal Lobe/*metabolism/pathology MH - Gene Expression Regulation/*drug effects MH - Hippocampus/*metabolism/pathology MH - Lithium/pharmacology MH - Lithium Chloride/*pharmacology MH - Male MH - Rats MH - Rats, Wistar MH - Stress, Psychological/drug therapy/*metabolism/pathology MH - bcl-X Protein/*biosynthesis EDAT- 2017/03/23 06:00 MHDA- 2017/03/23 06:01 CRDT- 2017/03/22 06:00 PHST- 2017/03/22 06:00 [entrez] PHST- 2017/03/23 06:00 [pubmed] PHST- 2017/03/23 06:01 [medline] AID - BCM82030487 [pii] AID - 10.1134/S0006297917030130 [doi] PST - ppublish SO - Biochemistry (Mosc). 2017 Mar;82(3):345-350. doi: 10.1134/S0006297917030130.