PMID- 28320591
OWN - NLM
STAT- MEDLINE
DCOM- 20171215
LR  - 20180207
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 35
IP  - 18
DP  - 2017 Apr 25
TI  - Minimal association of alleles of human leukocyte antigen class II gene and 
      long-term antibody response to hepatitis B vaccine vaccinated during infancy.
PG  - 2457-2462
LID - S0264-410X(17)30327-4 [pii]
LID - 10.1016/j.vaccine.2017.03.021 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA) system plays critical roles in 
      regulating immune responses to various vaccines. This study aimed to evaluate the 
      association of HLA class II gene polymorphisms and the long-term duration of 
      anti-HBs response in children vaccinated against hepatitis B during infancy. 
      METHODS: Totally 297 children 5-7years after the completion of primary 
      vaccination against hepatitis B in infancy, without booster immunization or 
      natural resolved infection, were enrolled. Of them, 86 children with anti-HBs 
      <10mIU/ml were considered as long-term non- or hypo-responders, and 211 others 
      with anti-HBs >/=10mIU/ml were defined as long-term responders. Ten alleles in 
      HLA-DR and -DQ subregions were detected by polymerase chain reaction with 
      sequence-specific primers. RESULTS: The frequency of HLA-DQB1 *0401 was 15.1% in 
      the long-term non- or hypo-responder group, relatively higher than 7.6% in the 
      long-term responder group (OR=2.17, 95% CI 1.01-4.73), however, the difference 
      had no statistical significance after Bonferroni correction (P=0.470). The 
      frequencies of seven HLA-DRB1 alleles, including  *01,  *03,  *04,  *07,  *08,  *11, 
      and  *1301/1302, and two HLA-DQB1 alleles, including  *0201 and  *0501, were each 
      similarly distributed in the long-term non- or hypo-responders and responders 
      respectively. CONCLUSION: None of the ten HLA class II gene alleles previously 
      reported to be related with short-term antibody response to hepatitis B vaccine 
      is associated with the long-term antibody response after vaccination during 
      infantile.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Xu, Biyun
AU  - Xu B
AD  - Departments of Experimental Medicine and Medical Statistics, Nanjing Drum Tower 
      Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University 
      Medical School, Jiangsu, China.
FAU - Zhu, Dongmei
AU  - Zhu D
AD  - Department of Infectious Diseases, Changzhou Third People's Hospital, Jiangsu, 
      China.
FAU - Bi, Yongchun
AU  - Bi Y
AD  - Departments of Experimental Medicine and Medical Statistics, Nanjing Drum Tower 
      Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University 
      Medical School, Jiangsu, China.
FAU - Wang, Yangyang
AU  - Wang Y
AD  - Departments of Experimental Medicine and Medical Statistics, Nanjing Drum Tower 
      Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University 
      Medical School, Jiangsu, China.
FAU - Hu, Yali
AU  - Hu Y
AD  - Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital and Jiangsu 
      Key Laboratory for Molecular Medicine, Nanjing University Medical School, 
      Jiangsu, China.
FAU - Zhou, Yi-Hua
AU  - Zhou YH
AD  - Departments of Experimental Medicine and Medical Statistics, Nanjing Drum Tower 
      Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University 
      Medical School, Jiangsu, China; Department of Infectious Diseases, Nanjing Drum 
      Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing 
      University Medical School, Jiangsu, China. Electronic address: 
      zgr03summer@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170318
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Antibody Formation/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hepatitis B/*prevention & control
MH  - Hepatitis B Antibodies/*blood
MH  - Hepatitis B Vaccines/*administration & dosage/*immunology
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Gene polymorphisms
OT  - Hepatitis B vaccine
OT  - Human leukocyte antigen
OT  - Long-term anti-HBs response
EDAT- 2017/03/23 06:00
MHDA- 2017/12/16 06:00
CRDT- 2017/03/22 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2017/02/07 00:00 [revised]
PHST- 2017/03/08 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/12/16 06:00 [medline]
PHST- 2017/03/22 06:00 [entrez]
AID - S0264-410X(17)30327-4 [pii]
AID - 10.1016/j.vaccine.2017.03.021 [doi]
PST - ppublish
SO  - Vaccine. 2017 Apr 25;35(18):2457-2462. doi: 10.1016/j.vaccine.2017.03.021. Epub 
      2017 Mar 18.