PMID- 28320987
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20170719
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 241
IP  - 3
DP  - 2017 Mar
TI  - Association between Mean Corpuscular Hemoglobin Concentration and Future 
      Depressive Symptoms in Women.
PG  - 209-217
LID - 10.1620/tjem.241.209 [doi]
AB  - Insufficient hemoglobin and depression share several symptoms and often occur in 
      the same patients. Here, we sought to clarify their relationship by investigating 
      two indices of oxygenation at the tissue level: mean corpuscular hemoglobin 
      concentration (MCHC) and hemoglobin level. We hypothesized that MCHC would be 
      more informative than hemoglobin levels. This prospective, longitudinal, 
      community-based study included 337 participants (108 men and 229 women; age 
      range, 38-87 years) who received evaluations of MCHC, hemoglobin levels and 
      depressive symptom scores (DSS) during baseline and follow-up examinations, which 
      were performed in 2008-2011 and 2010-2012, respectively. MCHC and hemoglobin 
      levels were measured as part of complete blood counts, while DSS was evaluated 
      using the Beck Depression Inventory. Associations were analyzed using linear 
      regression. We found a statistically significant association between baseline 
      MCHC and follow-up DSS (beta = -0.69, p = 0.026), which remained statistically 
      significant after controlling for potential confounders (beta = -0.71, p = 0.011). 
      Further, when we analyzed the relationship separately for men and women, we 
      observed that it remained stable for women before (beta = -1.00, p = 0.014) and 
      after (beta = -1.09, p = 0.003) adjusting for confounders. The stable association 
      indicates that MCHC may be superior to hemoglobin level as a prognostic factor 
      for future depressive symptoms in women. MCHC is easy to measure and low MCHC is 
      usually treatable. Therefore, screening and intervention efforts could be 
      targeted at women with low MCHC, who appear to have elevated risks of developing 
      depressive symptoms.
FAU - Lee, Ju-Mi
AU  - Lee JM
AD  - Department of Preventive Medicine, Yonsei University College of Medicine.
FAU - Nadimpalli, Sarah B
AU  - Nadimpalli SB
FAU - Yoon, Jin-Ha
AU  - Yoon JH
FAU - Mun, Se Yeon
AU  - Mun SY
FAU - Suh, Il
AU  - Suh I
FAU - Kim, Hyeon Chang
AU  - Kim HC
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Depression/*blood
MH  - *Erythrocyte Indices
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2017/03/23 06:00
MHDA- 2017/07/20 06:00
CRDT- 2017/03/22 06:00
PHST- 2017/03/22 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
AID - 10.1620/tjem.241.209 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2017 Mar;241(3):209-217. doi: 10.1620/tjem.241.209.