PMID- 28321030
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180326
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 64
IP  - 5
DP  - 2017 May 30
TI  - Pancreas volume reduction and metabolic effects in Japanese patients with severe 
      obesity following laparoscopic sleeve gastrectomy.
PG  - 487-498
LID - 10.1507/endocrj.EJ16-0321 [doi]
AB  - This study aimed to assess the relationship between the metabolic effect after 
      laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with 
      or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis 
      (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing 
      LSG. Their clinical and metabolic effects were evaluated at baseline and six 
      months after LSG. Pancreas volume (PV), pancreatic attenuation (PA), and splenic 
      attenuation (SA) were measured using a 64-row computed tomography (CT). Changes 
      in PV, PA-SA, and PA/SA were evaluated. The mean body-weight loss, body mass 
      index loss, and percentage of excess weight loss (%EWL) were -34.4 kg (p < 
      0.001), -11.0 kg/m(2) (p < 0.001), and 43.7%, respectively. The mean PV was 96.7 
      mL at baseline, and it decreased six months after LSG (-16.3mL, p < 0.001). The 
      mean PA significantly increased six months after LSG (9.5 HU, p < 0.001). PA-SA 
      (-23.2 HU vs. -13.3 HU, p = 0.003), and PA/SA (0.54 vs. 0.73, p < 0.001) also 
      significantly increased six months after LSG. In T2DM patients, decreased PV 
      correlated with decreased fasting blood sugar, decreased insulin, and reduced 
      liver volume. In conclusion, PV significantly decreased after LSG in morbidly 
      obese Japanese patients, and that decrease correlated with improvements in PS. In 
      addition, PS plays an important role of development and progression of insulin 
      resistance and T2DM.
FAU - Umemura, Akira
AU  - Umemura A
AD  - Department of Surgery, Iwate Medical University, Morioka 020-8505, Japan.
FAU - Sasaki, Akira
AU  - Sasaki A
AD  - Department of Surgery, Iwate Medical University, Morioka 020-8505, Japan.
FAU - Nitta, Hiroyuki
AU  - Nitta H
AD  - Department of Surgery, Iwate Medical University, Morioka 020-8505, Japan.
FAU - Baba, Shigeaki
AU  - Baba S
AD  - Department of Surgery, Iwate Medical University, Morioka 020-8505, Japan.
FAU - Ando, Taro
AU  - Ando T
AD  - Department of Surgery, Iwate Medical University, Morioka 020-8505, Japan.
FAU - Kajiwara, Takashi
AU  - Kajiwara T
AD  - Department of Internal Medicine, Division of Diabetes and Metabolism, Iwate 
      Medical University, Morioka 020-8505, Japan.
FAU - Ishigaki, Yasushi
AU  - Ishigaki Y
AD  - Department of Internal Medicine, Division of Diabetes and Metabolism, Iwate 
      Medical University, Morioka 020-8505, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170317
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Female
MH  - Gastrectomy/*methods
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Japan
MH  - Leptin/blood
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/diagnostic imaging/metabolism/pathology/*surgery
MH  - Organ Size/physiology
MH  - Pancreas/diagnostic imaging/*pathology
MH  - Retrospective Studies
MH  - Spleen/diagnostic imaging/pathology
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Weight Loss/physiology
OTO - NOTNLM
OT  - Ectopic fat
OT  - Laparoscopic sleeve gastrectomy
OT  - Pancreas volume
OT  - Type 2 diabetes mellitus
EDAT- 2017/03/23 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/03/22 06:00
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/03/22 06:00 [entrez]
AID - 10.1507/endocrj.EJ16-0321 [doi]
PST - ppublish
SO  - Endocr J. 2017 May 30;64(5):487-498. doi: 10.1507/endocrj.EJ16-0321. Epub 2017 
      Mar 17.