PMID- 28322314
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20201209
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Mar 21
TI  - The prognostic value of N-terminal proB-type natriuretic peptide in patients with 
      acute respiratory distress syndrome.
PG  - 44784
LID - 10.1038/srep44784 [doi]
LID - 44784
AB  - We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) 
      predicts the prognosis of patients with acute respiratory distress syndrome 
      (ARDS). Between December 1, 2012, and May 31, 2015, this observational study 
      recruited patients admitted to our tertiary medical center who met the Berlin 
      criteria for ARDS and who had their NT-proBNP measured. The main outcome was 
      28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 
      were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II 
      scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 
      8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median 
      level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died 
      during this study, and the 28-day mortality rate was 55.7%. Patients who die were 
      older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP 
      levels than did patients who survived. Multivariate analysis identified age (HR: 
      1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 
      1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was 
      associated with poor outcomes for patients with ARDS, and its level predicted 
      mortality.
FAU - Lai, Chih-Cheng
AU  - Lai CC
AD  - Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
FAU - Sung, Mei-I
AU  - Sung MI
AD  - Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Ho, Chung-Han
AU  - Ho CH
AD  - Departments of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Chia Nan University of Pharmacy &Science, Tainan, Taiwan.
FAU - Liu, Hsiao-Hua
AU  - Liu HH
AD  - Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Chen, Chin-Ming
AU  - Chen CM
AD  - Chia Nan University of Pharmacy &Science, Tainan, Taiwan.
AD  - Departments of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Chiang, Shyh-Ren
AU  - Chiang SR
AD  - Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Chia Nan University of Pharmacy &Science, Tainan, Taiwan.
FAU - Chao, Chien-Ming
AU  - Chao CM
AD  - Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
FAU - Liu, Wei-Lun
AU  - Liu WL
AD  - Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.
FAU - Hsing, Shu-Chen
AU  - Hsing SC
AD  - Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
FAU - Cheng, Kuo-Chen
AU  - Cheng KC
AD  - Departments of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Department of Safety Health and Environmental Engineering, Chung Hwa University 
      of Medical Technology, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Demography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*metabolism
MH  - Peptide Fragments/*metabolism
MH  - Prognosis
MH  - ROC Curve
MH  - Respiratory Distress Syndrome/*diagnosis/mortality
MH  - Survival Analysis
MH  - Treatment Outcome
PMC - PMC5359608
COIS- The authors declare no competing financial interests.
EDAT- 2017/03/23 06:00
MHDA- 2018/11/10 06:00
PMCR- 2017/03/21
CRDT- 2017/03/22 06:00
PHST- 2016/12/16 00:00 [received]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/03/22 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2017/03/21 00:00 [pmc-release]
AID - srep44784 [pii]
AID - 10.1038/srep44784 [doi]
PST - epublish
SO  - Sci Rep. 2017 Mar 21;7:44784. doi: 10.1038/srep44784.