PMID- 2832245
OWN - NLM
STAT- MEDLINE
DCOM- 19880512
LR  - 20220227
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 19
IP  - 2
DP  - 1988
TI  - GABAA and GABAB receptor sites involvement in rat thermoregulation.
PG  - 223-6
AB  - 1. Intraperitoneal (i.p.) injection of muscimol (MUS, 2-8 mg kg-1) decreased the 
      core body temperature (BT) of the rats dose-dependently. 2. 
      Intracerebroventricular (i.c.v.) injection of MUS (1 microgram/microliter/rat) 
      also caused a fall in BT. 3. The hypothermia induced by MUS was inhibited by 
      pretreatment of the animals with either bicuculline (BIC) or picrotoxin (PIC). 4. 
      i.p. Injection of baclofen (BAC, 2.5-10 mg kg-1) induced hypothermia. Higher dose 
      of the drug (20 mg kg-1) caused an initial fall followed by a marked increase in 
      BT. 5. i.c.v. Injection of BAC produced a rise in BT. 6. The hypothermic effect 
      of BAC was antagonized in animals pretreated with either BIC or PIC, while 
      hyperthermic effect of the drug was potentiated with PIC pretreatment. 7. i.c.v. 
      Injection of isoguvacine (ISO) induced hypothermia, which was attenuated in rats 
      pretreated with either BIC or PIC. 8. It can be concluded that: activation of 
      GABAA or GABAB receptor sites respectively may induce hypothermia or hyperthermia 
      in rats.
FAU - Zarrindast, M R
AU  - Zarrindast MR
AD  - Department of Pharmacology, Faculty of Medicine, University of Tehran, Iran.
FAU - Oveissi, Y
AU  - Oveissi Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Isonicotinic Acids)
RN  - 0 (Receptors, GABA-A)
RN  - 124-87-8 (Picrotoxin)
RN  - 2763-96-4 (Muscimol)
RN  - H789N3FKE8 (Baclofen)
RN  - Y37615DVKC (Bicuculline)
RN  - YTF580771Y (isoguvacine)
SB  - IM
MH  - Animals
MH  - Baclofen/pharmacology
MH  - Bicuculline/pharmacology
MH  - *Body Temperature Regulation
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Isonicotinic Acids/pharmacology
MH  - Male
MH  - Muscimol/administration & dosage/pharmacology
MH  - Picrotoxin/pharmacology
MH  - Rats
MH  - Receptors, GABA-A/*physiology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 0306-3623(88)90065-1 [pii]
AID - 10.1016/0306-3623(88)90065-1 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1988;19(2):223-6. doi: 10.1016/0306-3623(88)90065-1.