PMID- 28323283
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20220409
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 7
IP  - 3
DP  - 2017 Mar 21
TI  - Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse 
      barrel cortex and improved working memory via BDNF/TrkB pathway.
PG  - e1069
LID - 10.1038/tp.2017.41 [doi]
AB  - Stress-related memory deficit is correlated with dendritic spine loss. Physical 
      exercise improves memory function and promotes spinogenesis. However, no studies 
      have been performed to directly observe exercise-related effects on spine 
      dynamics, in association with memory function. This study utilized transcranial 
      two-photon in vivo microscopy to investigate dendritic spine formation and 
      elimination in barrel cortex of mice under physical constrain or naive 
      conditions, followed by memory performance in a whisker-dependent novel texture 
      discrimination task. We found that stressed mice had elevated spine elimination 
      rate in mouse barrel cortex plus deficits in memory retrieval, both of which can 
      be rescued by chronic exercise on treadmill. Exercise also elevated brain-derived 
      neurotrophic factor (BDNF) expression in barrel cortex. The above-mentioned 
      rescuing effects for both spinognesis and memory function were abolished after 
      inhibiting BDNF/tyrosine kinase B (TrkB) pathway. In summary, this study 
      demonstrated the improvement of stress-associated memory function by exercise via 
      facilitating spine retention in a BDNF/TrkB-dependent manner.
FAU - Chen, K
AU  - Chen K
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
AD  - Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China.
FAU - Tan, M
AU  - Tan M
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
FAU - Lai, C S W
AU  - Lai CS
AD  - School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
FAU - Li, A
AU  - Li A
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
FAU - Ren, C
AU  - Ren C
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
AD  - Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China.
FAU - So, K-F
AU  - So KF
AD  - Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan 
      University, Guangzhou, China.
AD  - Guangdong-Hong Kong-Macau Collaboration and Innovation Center for Tissue 
      Regeneration and Repair, Jinan University, Guangzhou, China.
AD  - Department of Ophthalmology and State Key Laboratory of Brain and Cognitive 
      Sciences, The University of Hong Kong, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170321
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - Behavior, Animal
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cerebral Cortex/*pathology
MH  - Dendritic Spines/*pathology
MH  - Intravital Microscopy
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Mice
MH  - Physical Conditioning, Animal/*physiology
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptor, trkB/genetics/metabolism
MH  - Restraint, Physical
MH  - Signal Transduction
MH  - Stress, Psychological/metabolism/pathology/*physiopathology
PMC - PMC5416682
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/23 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/03/01
CRDT- 2017/03/22 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/03/22 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - tp201741 [pii]
AID - 10.1038/tp.2017.41 [doi]
PST - epublish
SO  - Transl Psychiatry. 2017 Mar 21;7(3):e1069. doi: 10.1038/tp.2017.41.