PMID- 28323962
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20180515
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 102
IP  - 6
DP  - 2017 Jun 1
TI  - MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the 
      Dutch MEN1 Study Group.
PG  - 2083-2090
LID - 10.1210/jc.2016-3690 [doi]
AB  - OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN1) is associated with an 
      early-onset elevated breast cancer risk. This finding potentially has 
      implications for breast cancer screening for women with MEN1, and therefore it is 
      necessary to assess whether other risk factors are involved to identify those at 
      greatest risk. DESIGN: A cross-sectional case control study was performed using 
      the Dutch MEN1 cohort, including >90% of the adult Dutch MEN1 population. All 
      women with a confirmed MEN1 mutation received a questionnaire regarding cancer 
      family history and breast cancer-related endocrine and general cancer risk 
      factors. RESULTS: A total of 138 of 165 (84%) eligible women with MEN1 completed 
      the questionnaire. Eleven of the 138 women had breast cancer. Another 34 
      relatives with breast cancer were identified in the families of the included 
      women, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation, and 9 had 
      an unknown MEN1 status. The median age at breast cancer diagnosis of women with 
      MEN1 (n = 22) was 45 years (range, 30 to 80 years), in comparison with 57.5 years 
      (range, 40 to 85 years) in female relatives without MEN1 (n = 14; P = 0.03) and 
      61.2 years in the Dutch reference population. Known endocrine risk factors and 
      general risk factors were not different for women with and without breast cancer. 
      CONCLUSION: The increased breast cancer risk in MEN1 carriers was not related to 
      other known breast cancer risk factors or familial cancer history, and therefore 
      breast cancer surveillance from the age of 40 years for all women with MEN1 is 
      justifiable.
CI  - Copyright (c) 2017 Endocrine Society
FAU - van Leeuwaarde, Rachel S
AU  - van Leeuwaarde RS
AD  - Department of Endocrine Oncology, University Medical Center Utrecht, 3584 CX 
      Utrecht, The Netherlands.
FAU - Dreijerink, Koen M
AU  - Dreijerink KM
AD  - Department of Endocrine Oncology, University Medical Center Utrecht, 3584 CX 
      Utrecht, The Netherlands.
FAU - Ausems, Margreet G
AU  - Ausems MG
AD  - Department of Clinical Genetics, University Medical Center Utrecht, 3584 CX 
      Utrecht, The Netherlands.
FAU - Beijers, Hanneke J
AU  - Beijers HJ
AD  - Department of Endocrinology, Radboud University Medical Center, 6500 HB Nijmegen, 
      The Netherlands.
FAU - Dekkers, Olaf M
AU  - Dekkers OM
AD  - Department of Endocrinology and Metabolism, Leiden University Medical Center, 
      2333 ZA Leiden, The Netherlands.
AD  - Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA 
      Leiden, The Netherlands.
FAU - de Herder, Wouter W
AU  - de Herder WW
AD  - Department of Internal Medicine, Erasmus Medical Center, 3000 WB Rotterdam, The 
      Netherlands.
FAU - van der Horst-Schrivers, Anouk N
AU  - van der Horst-Schrivers AN
AD  - Department of Endocrinology, University of Groningen, University Medical Center 
      Groningen, 9700 VG Groningen, The Netherlands.
FAU - Drent, Madeleine L
AU  - Drent ML
AD  - Department of Internal Medicine, Section of Endocrinology, VU University Medical 
      Center, 1007 MB Amsterdam, The Netherlands.
FAU - Bisschop, Peter H
AU  - Bisschop PH
AD  - Department of Endocrinology and Metabolism, Academic Medical Center, 1105 AZ 
      Amsterdam, The Netherlands.
FAU - Havekes, Bas
AU  - Havekes B
AD  - Department of Internal Medicine, Division of Endocrinology, Maastricht University 
      Medical Center, 6202 AZ Maastricht, The Netherlands.
FAU - Peeters, Petra H M
AU  - Peeters PHM
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, 3584 CX Utrecht, The Netherlands.
FAU - Pijnappel, Ruud M
AU  - Pijnappel RM
AD  - Department of Radiology, University Medical Center Utrecht, 3584 CX Utrecht, The 
      Netherlands.
FAU - Vriens, Menno R
AU  - Vriens MR
AD  - Department of Endocrine Surgery, University Medical Center Utrecht, 3584 CX 
      Utrecht, The Netherlands.
FAU - Valk, Gerlof D
AU  - Valk GD
AD  - Department of Endocrine Oncology, University Medical Center Utrecht, 3584 CX 
      Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/diagnosis/*diagnostic imaging/etiology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - *Early Detection of Cancer
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Mammography
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Mutation
MH  - Netherlands
MH  - Risk Factors
EDAT- 2017/03/23 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/03/22 06:00
PHST- 2016/11/13 00:00 [received]
PHST- 2017/03/14 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2017/03/22 06:00 [entrez]
AID - 3074045 [pii]
AID - 10.1210/jc.2016-3690 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2017 Jun 1;102(6):2083-2090. doi: 10.1210/jc.2016-3690.