PMID- 28324025
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20221207
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 102
IP  - 5
DP  - 2017 May 1
TI  - Clinical and Genetic Features of Patients With Type 2 Diabetes and Renal 
      Glycosuria.
PG  - 1548-1556
LID - 10.1210/jc.2016-2332 [doi]
AB  - CONTEXT: A sodium glucose cotransporter 2 (SGLT2) inhibitor, which increases 
      urinary glucose excretion, was reported to decrease blood glucose levels and 
      deaths among patients with type 2 diabetes mellitus (T2DM) and established 
      cardiovascular disease. SLC5A2 and HNF1A mutations are associated with renal 
      glycosuria, but their contributions to renal glycosuria in patients with T2DM are 
      not well understood. OBJECTIVE: To assess the clinical features of patients with 
      T2DM and renal glycosuria and those with T2DM and low urinary glucose excretion 
      (LUGE) and identify variants in the exons of SLC5A2 and HNF1A in patients with 
      renal glycosuria and T2DM. DESIGN: A total of 2044 Chinese patients with T2DM, 
      including 64 patients with renal glycosuria and 58 patients with LUGE, were 
      tested for their plasma and urine glucose concentrations after fasting. SLC5A2 
      and HNF1A exons were sequenced. RESULTS: Compared with patients with LUGE, those 
      with renal glycosuria were younger (P = 0.008), had lower body mass index (BMI) 
      (P = 0.002) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) 
      values (P < 0.0001), and were less likely to have hypertension (P = 0.006). 
      HOMA-IR and BMI were negatively associated with renal glycosuria after adjusting 
      for age, sex, hypertension, and insulin therapy. One novel mutation (V359G) of 
      SLC5A2 in 32 patients with renal glycosuria and one known mutation (R131W) of 
      HNF1A in 28 nonobese patients with renal glycosuria were identified. CONCLUSIONS: 
      These findings suggest that there are subtypes of T2DM characterized by different 
      urinary glucose excretion and cardiovascular risk factors. SLC5A2 and HNF1A 
      mutations partially explain renal glycosuria in patients with T2DM.
CI  - Copyright (c) 2017 by the Endocrine Society
FAU - Gong, Siqian
AU  - Gong S
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
AD  - Peking University Diabetes Center, Beijing 100044, China.
FAU - Guo, Jiandong
AU  - Guo J
AD  - Department of Medicine, Beijing Yanqing Hospital, Beijing 102100, China.
FAU - Han, Xueyao
AU  - Han X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Li, Meng
AU  - Li M
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
AD  - Peking University Diabetes Center, Beijing 100044, China.
FAU - Zhou, Lingli
AU  - Zhou L
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Cai, Xiaoling
AU  - Cai X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Luo, Yingying
AU  - Luo Y
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Zhang, Simin
AU  - Zhang S
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Zhou, Xianghai
AU  - Zhou X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Ma, Yumin
AU  - Ma Y
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing 100044, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HNF1A protein, human)
RN  - 0 (Hepatocyte Nuclear Factor 1-alpha)
RN  - 0 (SLC5A2 protein, human)
RN  - 0 (Sodium-Glucose Transporter 2)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Asian People/genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*metabolism
MH  - Female
MH  - Genetic Variation
MH  - Glycosuria, Renal/epidemiology/*genetics
MH  - Hepatocyte Nuclear Factor 1-alpha/*genetics
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology
MH  - Sequence Analysis, DNA
MH  - Sodium-Glucose Transporter 2/*genetics
EDAT- 2017/03/23 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/03/22 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2017/01/19 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2017/03/22 06:00 [entrez]
AID - 2954944 [pii]
AID - 10.1210/jc.2016-2332 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2017 May 1;102(5):1548-1556. doi: 10.1210/jc.2016-2332.