PMID- 28324991
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2016
DP  - 2016 Aug
TI  - Features of cerebral oxygenation detects brain injury in premature infants.
PG  - 3614-3617
LID - 10.1109/EMBC.2016.7591510 [doi]
AB  - Babies born prematurely can develop brain injury within days after birth. Early 
      identification of high-risk infants enables appropriate clinical care to mitigate 
      potential lifelong disabilities. Near infra-red spectroscopy is an established 
      technology that can provide continuous measurements of cerebral oxygen saturation 
      (rcSO(2)) over this critical period. We develop a feature set of the rcSO(2) 
      signal for the purpose of detecting brain injury. Our feature set contains 
      amplitude, spectral, and fractal dimension features within 5 frequency bands. 
      Features are combined in a support vector machine (SVM) and performance is 
      assessed within a cross-validation procedure. Using a cohort of 47 infants of 
      <;32 weeks of gestation, we find significant (p <; 0.05) features of amplitude in 
      the frequency band 0.9-3.6 mHz and a fractal dimension measure in the frequency 
      band 1.8-3.6 mHz. The SVM has an area-under the receiver operator characteristic 
      (AUC) of 0.75 with sensitivity-specificity values of 67-77%. These moderate 
      results highlight the potential for quantitative analysis of rcSO(2) to detect 
      brain injury and thus enable early identification of high-risk infants.
FAU - O'Toole, John M
AU  - O'Toole JM
FAU - Kenosi, Mmoloki
AU  - Kenosi M
FAU - Finn, Daragh
AU  - Finn D
FAU - Boylan, Geraldine B
AU  - Boylan GB
FAU - Dempsey, Eugene M
AU  - Dempsey EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Brain Injuries/*diagnosis
MH  - Cohort Studies
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Infant, Premature, Diseases/*diagnosis
MH  - Oxygen/analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Signal Processing, Computer-Assisted
MH  - Spectroscopy, Near-Infrared/*methods
MH  - Support Vector Machine
EDAT- 2016/01/01 00:00
MHDA- 2017/06/27 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/03/23 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
AID - 10.1109/EMBC.2016.7591510 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:3614-3617. doi: 
      10.1109/EMBC.2016.7591510.