PMID- 28325293
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2162-2531 (Print)
IS  - 2162-2531 (Electronic)
IS  - 2162-2531 (Linking)
VI  - 6
DP  - 2017 Mar 17
TI  - A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by 
      Inhibiting Apoptosis in Lung Squamous Cell Carcinoma.
PG  - 269-278
LID - S2162-2531(17)30123-3 [pii]
LID - 10.1016/j.omtn.2017.01.003 [doi]
AB  - Lung cancer is the leading cause of cancer-related death worldwide. Although 
      advanced drugs have benefitted patients, therapeutic success has largely been 
      hampered because of rapid development of resistance. Here we report that 
      PIWI-interacting RNA likes (piR-Ls), a novel type of functional sncRNAs, play key 
      roles in chemoresistance to cisplatin (CDDP)-based chemotherapy in lung squamous 
      cell carcinoma (LSCC). piR-L-138 was upregulated upon CDDP-based chemotherapy 
      both in LSCC cells and in patient-derived xenograft (PDX) LSCC models. Further, 
      targeting upregulated piR-L-138 led to increased apoptosis in CDDP-treated LSCC 
      cells and LSCC xenograft mice treated with CDDP. In addition, piR-L-138 directly 
      interacted with p60-MDM2 and inhibited CDDP-activated apoptosis in p53-mutated 
      LSCC. We identified the upregulated piR-L-138 upon CDDP-based chemotherapy, 
      confirmed the enhanced sensitivity of LSCC to agents by targeting the upregulated 
      piR-L-138 both in vitro and in vivo, and revealed mechanisms underlying piR-L-138 
      in chemoresistance, bolstering a new emerging clinical modality where novel 
      functional piR-Ls provide potential strategies to overcome chemoresistance for 
      patients with LSCC.
CI  - Copyright (c) 2017 Department of Oncology and Diagnostic Science, University of 
      Maryland School of Dentistry. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Yuyan
AU  - Wang Y
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA; Department of Thoracic 
      Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research 
      (Ministry of Education), Peking University Cancer Hospital and Beijing Institute 
      for Cancer Research, Beijing 100142, China.
FAU - Gable, Tyler
AU  - Gable T
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA.
FAU - Ma, Mark Z
AU  - Ma MZ
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA.
FAU - Clark, David
AU  - Clark D
AD  - Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
FAU - Zhao, Jun
AU  - Zhao J
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA; Department of Thoracic 
      Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research 
      (Ministry of Education), Peking University Cancer Hospital and Beijing Institute 
      for Cancer Research, Beijing 100142, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Thoracic Surgery, Lung Cancer Center, Xuanwu Hospital, Capital 
      Medical University, Beijing 100053, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou 510630, China.
FAU - Mao, Li
AU  - Mao L
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA.
FAU - Mei, Yuping
AU  - Mei Y
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland School of 
      Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA. Electronic address: 
      ymei@umaryland.edu.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - United States
TA  - Mol Ther Nucleic Acids
JT  - Molecular therapy. Nucleic acids
JID - 101581621
PMC - PMC5363509
OTO - NOTNLM
OT  - chemoresistance
OT  - lung cancer
OT  - piRNA-likes
OT  - sncRNA
EDAT- 2017/03/23 06:00
MHDA- 2017/03/23 06:01
PMCR- 2017/01/24
CRDT- 2017/03/23 06:00
PHST- 2016/08/30 00:00 [received]
PHST- 2016/12/21 00:00 [revised]
PHST- 2017/01/11 00:00 [accepted]
PHST- 2017/03/23 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/03/23 06:01 [medline]
PHST- 2017/01/24 00:00 [pmc-release]
AID - S2162-2531(17)30123-3 [pii]
AID - 10.1016/j.omtn.2017.01.003 [doi]
PST - ppublish
SO  - Mol Ther Nucleic Acids. 2017 Mar 17;6:269-278. doi: 10.1016/j.omtn.2017.01.003. 
      Epub 2017 Jan 24.