PMID- 28325338
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 164
DP  - 2017 May 15
TI  - Physicochemical properties and antidiabetic effects of a polysaccharide from corn 
      silk in high-fat diet and streptozotocin-induced diabetic mice.
PG  - 370-378
LID - S0144-8617(17)30103-0 [pii]
LID - 10.1016/j.carbpol.2017.01.092 [doi]
AB  - This study aimed to investigate the physicochemical properties and antidiabetic 
      effects of a polysaccharide obtained from corn silk (PCS2). PCS2 was isolated and 
      the physicochemical properties were characterized. The hypoglycemic effects were 
      determined using the high-fat diet and streptozocin induced type 2 diabetic 
      mellitus (T2DM) insulin resistance mice. The results showed that PCS2 was a 
      heteropolysaccharide with the average molecular weight of 45.5kDa. PCS2 was 
      composed of d-galactose, d-mannose, d-(+)-glucose, d-(+)-xylose, l-arabinose and 
      l-rhamnose. PCS2 treatment significantly reduced the body weight loss, decreased 
      blood glucose and serum insulin levels, and improved glucose intolerance 
      (P<0.05). The levels of serum lipid profile were regulated and the levels of 
      glycated serum protein, non-esterified fatty acid were decreased significantly 
      (P<0.01). The activities of superoxide dismutase, glutathione peroxidase and 
      catalase were notably improved (P<0.05). PCS2 also exerted cytoprotective action 
      from histopathological observation. These results suggested that PCS2 could be a 
      good candidate of functional food or medicine for T2DM treatment.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Pan, Yuxiang
AU  - Pan Y
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China.
FAU - Wang, Cong
AU  - Wang C
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China.
FAU - Chen, Zhongqin
AU  - Chen Z
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China.
FAU - Li, Weiwei
AU  - Li W
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China.
FAU - Yuan, Guoqi
AU  - Yuan G
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China.
FAU - Chen, Haixia
AU  - Chen H
AD  - Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of 
      Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR 
      China. Electronic address: chenhx@tju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170129
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Lipids)
RN  - 0 (Polysaccharides)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Diet, High-Fat
MH  - Hypoglycemic Agents/*pharmacology
MH  - Lipids/blood
MH  - Male
MH  - Mice
MH  - Polysaccharides/*pharmacology
MH  - Streptozocin
MH  - Zea mays/*chemistry
OTO - NOTNLM
OT  - Antidiabetic effects
OT  - Characterization
OT  - Corn silk polysaccharides
OT  - T2DM mice
EDAT- 2017/03/23 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/03/23 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/01/23 00:00 [revised]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/03/23 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
AID - S0144-8617(17)30103-0 [pii]
AID - 10.1016/j.carbpol.2017.01.092 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 May 15;164:370-378. doi: 10.1016/j.carbpol.2017.01.092. 
      Epub 2017 Jan 29.