PMID- 28325597
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20181202
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 225
DP  - 2017 Jun
TI  - Relationships between acrylamide and glycidamide hemoglobin adduct levels and 
      allergy-related outcomes in general US population, NHANES 2005-2006.
PG  - 506-513
LID - S0269-7491(17)30145-8 [pii]
LID - 10.1016/j.envpol.2017.03.016 [doi]
AB  - BACKGROUND: Acrylamide-induced immunotoxicity and allergic dermatitis have been 
      reported in animal experiments and clinical reports, respectively. However, 
      epidemiological evidence from the general population is limited. OBJECTIVES: The 
      purpose of the present study was to estimate the associations between acrylamide 
      exposure and allergy-related outcomes in the general US population. METHODS: A 
      total of 6982 subjects were selected from the National Health and Nutrition 
      Examination Survey 2005-2006 (NHANES). Internal exposure was measured by the 
      hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA). 
      Allergy-related outcomes including asthma, hay fever, allergy, itchy rash, 
      sneeze, wheeze and eczema were obtained by self-administered questionnaires. 
      Allergic sensitization was assessed by the total immunoglobulin E (IgE) levels. 
      The associations of HbAA and HbGA quartiles with allergy-related outcomes were 
      calculated using logistic regression models with multivariable adjustments. 
      Analyses were additionally stratified according to age, gender and serum cotinine 
      levels. RESULTS: When setting quartile 1 of HbAA as reference, the odds ratios 
      (ORs) [95% confidence intervals (CIs)] of quartile 2 to 4 for eczema were 1.18 
      (0.79-1.76), 1.14 (0.73-1.78) and 1.58 (1.14-2.18), respectively 
      (p(trend) = 0.002). Individuals at the highest quartile of HbGA had significantly 
      elevated likelihoods of itchy rash (OR = 1.37, 95% CI = 1.02-1.83, 
      p(trend) = 0.032) and eczema (OR = 1.45, 95% CI = 1.06-1.97, p(trend) = 0.044). 
      The stratification analyses indicated various results in different subgroups. 
      CONCLUSIONS: This study indicated significant associations between HbAA and HbGA 
      levels and the likelihoods of allergy-related outcomes in the general US 
      population, depending on age, gender and smoke exposure status. These findings 
      suggested potential public health concerns for the widespread exposure to 
      acrylamide.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Guo, Jing
AU  - Guo J
AD  - Institute of Environmental Health, Department of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Yu, Dongdong
AU  - Yu D
AD  - Institute of Environmental Health, Department of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Lv, Na
AU  - Lv N
AD  - Institute of Environmental Health, Department of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Bai, Rongpan
AU  - Bai R
AD  - Institute of Environmental Health, Department of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Xu, Chunjing
AU  - Xu C
AD  - Department of Obstetrics, Women's Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Chen, Guangdi
AU  - Chen G
AD  - Institute of Environmental Health, Department of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, China. Electronic address: 
      chenguangdi@zju.edu.cn.
FAU - Cao, Weiming
AU  - Cao W
AD  - School of Humanities and Social Sciences, Zhejiang Chinese Medical University, 
      Hangzhou, China. Electronic address: cwm@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170318
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Epoxy Compounds)
RN  - 0 (Hemoglobins)
RN  - 20R035KLCI (Acrylamide)
RN  - 6G5ELX5XYN (glycidamide)
SB  - IM
MH  - Acrylamide/*metabolism/toxicity
MH  - Adult
MH  - Animals
MH  - Asthma
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Epoxy Compounds/*metabolism/toxicity
MH  - Female
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Hypersensitivity
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Odds Ratio
MH  - Rhinitis, Allergic, Seasonal
MH  - United States
OTO - NOTNLM
OT  - Acrylamide
OT  - Allergy
OT  - Glycidamide
OT  - Hemoglobin adducts
OT  - NHANES
EDAT- 2017/03/23 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/02/22 00:00 [revised]
PHST- 2017/03/07 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - S0269-7491(17)30145-8 [pii]
AID - 10.1016/j.envpol.2017.03.016 [doi]
PST - ppublish
SO  - Environ Pollut. 2017 Jun;225:506-513. doi: 10.1016/j.envpol.2017.03.016. Epub 
      2017 Mar 18.