PMID- 28325685
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20180107
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 128
DP  - 2017 Jun
TI  - A positive feedback strategy for enhanced chemotherapy based on ROS-triggered 
      self-accelerating drug release nanosystem.
PG  - 136-146
LID - S0142-9612(17)30153-9 [pii]
LID - 10.1016/j.biomaterials.2017.03.010 [doi]
AB  - Here, a positive feedback strategy was utilized to amplify the concentration of 
      intracellular reactive oxygen species (ROS) and a ROS-triggered self-accelerating 
      drug release nanosystem (defined as T/D@RSMSNs) was demonstrated for enhanced 
      tumor chemotherapy. The mesoporous silica nanoparticles (MSNs) based nanocarriers 
      were gated by beta-cyclodextrin (beta-CD) through the ROS-cleavable thioketal (TK) 
      linker to encapsulate the anticancer drug doxorubicin hydrochloride (DOX) and ROS 
      producing agent alpha-tocopheryl succinate (alpha-TOS), whose surface was further 
      anchored with adamantane conjugated poly(ethylene glycol) chain (AD-PEG) via 
      host-guest interaction. It was found that in human breast cancer (MCF-7) cells, 
      T/D@RSMSNs could not only release DOX and alpha-TOS initiatively, but also lead to 
      increased concentration of intracellular ROS, which could be used as new trigger 
      to cut away TK linkage and then in turn facilitate the further release of DOX for 
      enhanced chemotherapy. Both in vitro and in vivo experiments demonstrated that 
      T/D@RSMSNs exhibited more significant antitumor activity in the human breast 
      cancer than the traditional single-DOX loaded ROS-responsive nanocarrier. This 
      novel ROS-triggered self-accelerating drug release nanosystem with remarkably 
      improved therapeutic effects could provide a general strategy to branch out the 
      applications of existing ROS-responsive drug delivery systems (DDSs).
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Hu, Jing-Jing
AU  - Hu JJ
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China.
FAU - Lei, Qi
AU  - Lei Q
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China.
FAU - Peng, Meng-Yun
AU  - Peng MY
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China.
FAU - Zheng, Di-Wei
AU  - Zheng DW
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China.
FAU - Chen, Yi-Xuan
AU  - Chen YX
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China.
FAU - Zhang, Xian-Zheng
AU  - Zhang XZ
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, PR China. Electronic address: 
      xz-zhang@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170311
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Reactive Oxygen Species)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Cell Death/drug effects
MH  - Cell Survival/drug effects
MH  - *Drug Delivery Systems
MH  - *Drug Liberation
MH  - *Feedback, Physiological
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - MCF-7 Cells
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Porosity
MH  - Reactive Oxygen Species/*metabolism
MH  - Silicon Dioxide/chemistry
MH  - alpha-Tocopherol/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Drug delivery
OT  - Mesoporous silica nanoparticle
OT  - Positive feedback strategy
OT  - ROS-responsive
OT  - Tumor therapy
EDAT- 2017/03/23 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/02/19 00:00 [revised]
PHST- 2017/03/10 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - S0142-9612(17)30153-9 [pii]
AID - 10.1016/j.biomaterials.2017.03.010 [doi]
PST - ppublish
SO  - Biomaterials. 2017 Jun;128:136-146. doi: 10.1016/j.biomaterials.2017.03.010. Epub 
      2017 Mar 11.