PMID- 28326889
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 24
IP  - 3
DP  - 2018 Mar
TI  - Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A 
      predominantly population-based study.
PG  - 331-339
LID - 10.1177/1352458517699791 [doi]
AB  - BACKGROUND: Serum immunoglobulin G targeting the astrocyte water channel 
      aquaporin-4 (AQP4) in the central nervous system (CNS) is a biomarker for 
      neuromyelitis optica spectrum disease (NMOSD). Co-existence of NMOSD with 
      systemic lupus erythematosus (SLE) putatively suggests susceptibility to 
      antibody-mediated autoimmune disease. OBJECTIVE: To estimate the prevalence of 
      NMOSD in SLE and investigate the immunogenetic background for an association of 
      NMOSD and SLE. METHODS: The study included a predominantly population-based 
      cohort with clinical and serological investigations of 208 patients with SLE, 
      followed prospectively since 1995. All patients received immunosuppressive 
      treatment. NMOSD was evaluated retrospectively based on the 2015 International 
      Panel for NMOSD Diagnosis (IPND) criteria. Polymorphisms in programmed cell death 
      protein 1 (PDCD-1) PD-1.3 G/A were genotyped. AGP4-IgG and other autoantibodies, 
      including myelin oligodendrocyte glycoprotein (MOG), was determined blinded to 
      clinical diagnosis. RESULTS: Of 208 patients with SLE, 45(22%) had 
      neuropsychiatric (NP) SLE, and CNS involvement predominated in 30 of 45 (67%) 
      patients. Serum AQP4-IgG was detected in 2 of 30 (6.7%) neuropsychiatric SLE 
      (NPSLE) patients both of whom had myelitis and antiphospholipid syndrome; one 
      patient also had myasthenia gravis. None had MOG-IgG. PD-1.3A allele was not 
      associated with SLE nor with NPSLE. CONCLUSION: AQP4-IgG autoimmune syndrome may 
      rarely co-exist with SLE, and such patients have other NMOSD-typical syndromes 
      such as myelitis.
FAU - Asgari, Nasrin
AU  - Asgari N
AD  - Neurobiology Research, Department of Molecular Medicine, University of Southern 
      Denmark, Odense, Denmark/Institute of Regional Health Research, University of 
      Southern Denmark, Odense, Denmark.
FAU - Jarius, Sven
AU  - Jarius S
AD  - Division of Molecular Neuroimmunology, Department of Neurology, Heidelberg 
      University, Heidelberg, Germany.
FAU - Laustrup, Helle
AU  - Laustrup H
AD  - Department of Rheumatology, Odense University Hospital, Odense, Denmark.
FAU - Skejoe, Hanne Pb
AU  - Skejoe HP
AD  - Department of Radiology, Aleris-Hamlet Hospital, Copenhagen, Denmark.
FAU - Lillevang, Soeren T
AU  - Lillevang ST
AD  - Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
FAU - Weinshenker, Brian G
AU  - Weinshenker BG
AD  - Department of Neurology, Mayo Clinic, Rochester, MN, USA.
FAU - Voss, Anne
AU  - Voss A
AD  - Department of Rheumatology, Odense University Hospital, Odense, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170322
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunosuppressive Agents)
MH  - Adult
MH  - *Antiphospholipid Syndrome/blood/epidemiology/immunology
MH  - Aquaporin 4/*immunology
MH  - Autoantibodies/*blood
MH  - Autoimmunity/immunology
MH  - Comorbidity
MH  - Denmark/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunosuppressive Agents
MH  - *Lupus Erythematosus, Systemic/blood/epidemiology/immunology
MH  - *Lupus Vasculitis, Central Nervous System/blood/epidemiology/immunology
MH  - Male
MH  - Middle Aged
MH  - *Neuromyelitis Optica/blood/epidemiology/immunology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Epidemiology
OT  - aquaporin-IgG
OT  - myelin oligodendrocyte glycoprotein-IgG
OT  - neuromyelitis optica spectrum disease
OT  - programmed death 1
OT  - systemic lupus erythematosus
EDAT- 2017/03/23 06:00
MHDA- 2019/07/28 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - 10.1177/1352458517699791 [doi]
PST - ppublish
SO  - Mult Scler. 2018 Mar;24(3):331-339. doi: 10.1177/1352458517699791. Epub 2017 Mar 
      22.