PMID- 28326910
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20180816
IS  - 1552-4531 (Electronic)
IS  - 0748-7304 (Linking)
VI  - 32
IP  - 1
DP  - 2017 Feb
TI  - Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and 
      Women.
PG  - 75-82
LID - 10.1177/0748730417693124 [doi]
AB  - The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) 
      has been proposed to be a marker of disease and an indicator of recovery. Thus, 
      knowing the temporal pattern and influence of potential circadian rhythms is 
      important. Although several studies have measured BDNF at different times of day, 
      no studies have done so while controlling for potential masking influences such 
      as sleep and activity. Further, no previous study has examined circadian rhythms 
      within individuals. We examined circadian rhythms in plasma BDNF while minimizing 
      masking from behavioral and environmental factors using a 30-h constant routine 
      (CR) protocol. In a sample of 39 healthy adults, we found significant circadian 
      rhythms in 75% of women and 52% of men. The timing of the acrophase of the BDNF 
      rhythm, however, was unrelated to clock time in women, while it was related to 
      clock time in men. These results indicate that the use of single-sample measures 
      of plasma BDNF as a marker of disease will be unreliable, especially in women. 
      Repeated plasma BDNF samples over a 24-h period within individuals would be 
      needed to reveal abnormalities related to disease states.
FAU - Cain, Sean W
AU  - Cain SW
AD  - Division of Sleep and Circadian Disorders, Department of Medicine and Department 
      of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Division of Sleep and Circadian Disorders, Harvard Medical School, Boston, 
      Massachusetts, USA.
AD  - School of Psychological Sciences and Monash Institute of Cognitive and Clinical 
      Neurosciences, Monash University, Clayton, Victoria, Australia.
FAU - Chang, Anne-Marie
AU  - Chang AM
AD  - Division of Sleep and Circadian Disorders, Department of Medicine and Department 
      of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Division of Sleep and Circadian Disorders, Harvard Medical School, Boston, 
      Massachusetts, USA.
AD  - Department of Biobehavioral Health, Pennsylvania State University, University 
      Park, Pennsylvania, USA.
FAU - Vlasac, Irma
AU  - Vlasac I
AD  - Center for Human Genetic Research and Department of Anesthesia, Critical Care and 
      Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
FAU - Tare, Archana
AU  - Tare A
AD  - Center for Human Genetic Research and Department of Anesthesia, Critical Care and 
      Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
FAU - Anderson, Clare
AU  - Anderson C
AD  - Division of Sleep and Circadian Disorders, Department of Medicine and Department 
      of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Division of Sleep and Circadian Disorders, Harvard Medical School, Boston, 
      Massachusetts, USA.
AD  - School of Psychological Sciences and Monash Institute of Cognitive and Clinical 
      Neurosciences, Monash University, Clayton, Victoria, Australia.
FAU - Czeisler, Charles A
AU  - Czeisler CA
AD  - Division of Sleep and Circadian Disorders, Department of Medicine and Department 
      of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Division of Sleep and Circadian Disorders, Harvard Medical School, Boston, 
      Massachusetts, USA.
FAU - Saxena, Richa
AU  - Saxena R
AD  - Division of Sleep and Circadian Disorders, Department of Medicine and Department 
      of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Center for Human Genetic Research and Department of Anesthesia, Critical Care and 
      Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
AD  - Medical and Population Genetics, Broad Institute of Harvard and Massachusetts 
      Institute of Technology, Cambridge, Massachusetts, USA.
LA  - eng
PT  - Journal Article
DEP - 20170220
PL  - United States
TA  - J Biol Rhythms
JT  - Journal of biological rhythms
JID - 8700115
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Circadian Clocks/*physiology
MH  - Circadian Rhythm/*physiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Sex Factors
MH  - Sleep/*physiology
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Val66Met
OT  - brain derived neurotrophic factor
OT  - circadian
OT  - constant routine
OT  - sex differences
EDAT- 2017/03/23 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/03/23 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
AID - 10.1177/0748730417693124 [doi]
PST - ppublish
SO  - J Biol Rhythms. 2017 Feb;32(1):75-82. doi: 10.1177/0748730417693124. Epub 2017 
      Feb 20.