PMID- 28327994
OWN - NLM
STAT- MEDLINE
DCOM- 20180425
LR  - 20181202
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 81
IP  - 1
DP  - 2017 Jul 1
TI  - Quality of Life following Stereotactic Radiosurgery for Single and Multiple Brain 
      Metastases.
PG  - 147-155
LID - 10.1093/neuros/nyw166 [doi]
AB  - BACKGROUND: Given the neurological morbidity and poor prognosis associated with 
      brain metastases, it is critical to deliver appropriate therapy while remaining 
      mindful of patient quality of life (QOL). For many patients, stereotactic 
      radiosurgery (SRS) effectively controls intracranial disease, but QOL outcomes 
      have not been characterized. OBJECTIVE: To determine the effect of number of 
      brain metastases upon QOL preservation following SRS. METHODS: The EuroQol 5 
      Dimensions questionnaire (EQ-5D) and Patient Health Questionnaire 9 instruments 
      were prospectively collected from a cohort of patients undergoing SRS for brain 
      metastasis between 2008 and 2015. These instruments served as measures of overall 
      QOL and depression. QOL deterioration exceeding the minimum clinically important 
      difference was considered failure. Freedom from 12-month EQ-5D index failure was 
      the primary outcome. RESULTS: One hundred and twenty-two SRS treatments (67 
      patients, 421 lesions) were eligible for inclusion. Intracranial failure (local 
      or distant) occurred following 61% of treatments. Among 421 lesions, 8% 
      progressed locally. Median follow-up was 12 months. CONCLUSIONS: Among patients 
      with brain metastasis, QOL preservation must remain paramount as multimodality 
      therapy continues to improve. In the present investigation, 12-month QOL 
      preservation was 79%. However, patients with more than 3 brain metastases were at 
      significantly greater risk for QOL decline.
CI  - Copyright (c) 2017 by the Congress of Neurological Surgeons
FAU - Miller, Jacob A
AU  - Miller JA
AD  - Cleveland Clinic Lerner College of Medi-cine, Cleveland Clinic, Cleveland, Ohio.
FAU - Kotecha, Rupesh
AU  - Kotecha R
AD  - Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Barnett, Gene H
AU  - Barnett GH
AD  - Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Suh, John H
AU  - Suh JH
AD  - Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 
      Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Angelov, Lilyana
AU  - Angelov L
AD  - Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Murphy, Erin S
AU  - Murphy ES
AD  - Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 
      Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Vogelbaum, Michael A
AU  - Vogelbaum MA
AD  - Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Mohammadi, Alireza
AU  - Mohammadi A
AD  - Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
FAU - Chao, Samuel T
AU  - Chao ST
AD  - Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 
      Cleveland, Ohio.
AD  - Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, 
      Cleveland, Ohio.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/complications/*radiotherapy/*secondary
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - *Radiosurgery
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Depression
OT  - Metastasis
OT  - Quality of life
OT  - Stereotactic radiosurgery
EDAT- 2017/03/23 06:00
MHDA- 2018/04/26 06:00
CRDT- 2017/03/23 06:00
PHST- 2016/01/25 00:00 [received]
PHST- 2016/12/25 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/04/26 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - 3048644 [pii]
AID - 10.1093/neuros/nyw166 [doi]
PST - ppublish
SO  - Neurosurgery. 2017 Jul 1;81(1):147-155. doi: 10.1093/neuros/nyw166.