PMID- 28328066
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180403
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 77
IP  - 5
DP  - 2017 May
TI  - Maternal obesity and inflammatory mediators: A controversial association.
LID - 10.1111/aji.12674 [doi]
AB  - The link between maternal obesity and inflammatory mediators is still unclear. 
      Our aim was to summarize the main findings of recently published studies on this 
      topic. We performed a search in Medline for studies published in the last years 
      on obesity, human pregnancy, and inflammatory mediators. We report the findings 
      of 30 studies. The characteristics and number of participants, study design, 
      gestational age at sample collection, and type of sample varied widely. 
      Approximately two-thirds of them investigated more than one mediator, and 50% 
      included participants in only one trimester of pregnancy. The most frequently 
      investigated mediators were leptin, tumour necrosis factor-alpha (TNF-alpha), and 
      interleukin (IL)-6. Almost all studies reported an association between maternal 
      obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1beta and 
      IL-10. The association of IL-6, TNF-alpha, monocyte chemo-attractant protein-1 
      (MCP-1), adiponectin, and resistin with maternal obesity is still controversial. 
      To clarify the physiopathological link between maternal obesity and inflammation, 
      more high-quality studies are needed.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Pendeloski, Karen Priscilla Tezotto
AU  - Pendeloski KPT
AD  - Department of Obstetrics, Universidade Federal de Sao Paulo, Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Ono, Erika
AU  - Ono E
AD  - Department of Obstetrics, Universidade Federal de Sao Paulo, Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Torloni, Maria Regina
AU  - Torloni MR
AD  - Department of Obstetrics, Universidade Federal de Sao Paulo, Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Mattar, Rosiane
AU  - Mattar R
AD  - Department of Obstetrics, Universidade Federal de Sao Paulo, Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Daher, Silvia
AU  - Daher S
AUID- ORCID: 0000-0001-5312-7804
AD  - Department of Obstetrics, Universidade Federal de Sao Paulo, Sao Paulo, Sao 
      Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170322
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Female
MH  - Humans
MH  - Inflammation/*complications
MH  - Inflammation Mediators/*analysis
MH  - Obesity/*complications
MH  - Pregnancy
MH  - *Pregnancy Complications
OTO - NOTNLM
OT  - adipokine
OT  - cytokine
OT  - inflammatory mediator
OT  - maternal obesity
OT  - pregnancy
EDAT- 2017/03/23 06:00
MHDA- 2018/01/03 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/01/19 00:00 [received]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - 10.1111/aji.12674 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12674. Epub 2017 Mar 22.