PMID- 28328533
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180816
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 30
IP  - 5
DP  - 2017 May 1
TI  - Plasma but not serum brain-derived neurotrophic factor concentration is decreased 
      by oral glucose tolerance test-induced hyperglycemia in children.
PG  - 525-530
LID - /j/jpem.2017.30.issue-5/jpem-2016-0344/jpem-2016-0344.xml [pii]
LID - 10.1515/jpem-2016-0344 [doi]
AB  - BACKGROUND: Little is known regarding the relationships among circulating 
      brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in 
      children and adolescents. The objective of this study was to investigate whether 
      circulating BDNF levels would change during the oral glucose tolerance test 
      (OGTT). METHODS: We performed the OGTT and measured the serial changes in BDNF 
      levels in both plasma and serum. RESULTS: There were 22 subjects in the normal 
      type (N) group and 20 in the borderline/diabetic type (B/D) group, defined by the 
      results of the OGTT. Serum levels of BDNF were almost five times higher and 
      plasma levels gradually decreased during the OGTT, whereas serum levels showed no 
      significant change. The reduction of plasma BDNF level changes from baseline to 
      120 min were significantly different between the N and B/D groups (36.3% vs. 
      20.8%, p=0.023). CONCLUSIONS: Our results showed that plasma levels of BDNF are 
      more sensitive to acute changes in glucose or insulin levels than serum.
FAU - Araki, Shunsuke
AU  - Araki S
FAU - Yamamoto, Yukiyo
AU  - Yamamoto Y
FAU - Saito, Reiko
AU  - Saito R
FAU - Kawakita, Aoi
AU  - Kawakita A
FAU - Eguchi, Mami
AU  - Eguchi M
FAU - Goto, Motohide
AU  - Goto M
FAU - Kubo, Kazuyasu
AU  - Kubo K
FAU - Kawagoe, Rinko
AU  - Kawagoe R
FAU - Kawada, Yasusada
AU  - Kawada Y
FAU - Kusuhara, Koichi
AU  - Kusuhara K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Female
MH  - Glucose Tolerance Test/*adverse effects
MH  - Humans
MH  - Hyperglycemia/*etiology
MH  - Insulin/blood
MH  - Male
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - child and adolescents
OT  - glucose tolerance test
OT  - insulin
OT  - platelets
EDAT- 2017/03/23 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/03/23 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2017/02/02 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - /j/jpem.2017.30.issue-5/jpem-2016-0344/jpem-2016-0344.xml [pii]
AID - 10.1515/jpem-2016-0344 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2017 May 1;30(5):525-530. doi: 
      10.1515/jpem-2016-0344.