PMID- 28328978
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 3
DP  - 2017
TI  - Thickness of retinal layers in the foveas of children with anisometropic 
      amblyopia.
PG  - e0174537
LID - 10.1371/journal.pone.0174537 [doi]
LID - e0174537
AB  - PURPOSE: To use highly precise spectral-domain optical coherence tomography 
      (SD-OCT) to determine whether there were structural abnormalities in the layers 
      of different regions of the fovea in children with anisometropic amblyopia. 
      METHODS: Eighteen children (mean age 7.8 years old; range 5-11 years) with 
      unilateral anisometropic amblyopia and 18 age-matched control subjects 
      participated. Foveal thickness was measured with an enhanced depth imaging 
      system, SD-OCT and segmented into layers using custom developed software. The 
      thickness of each layer of the fovea was compared among amblyopic eyes, fellow 
      eyes and control eyes with optical magnification correction for axial length and 
      statistical correction for age and sex. RESULTS: The total thickness and each 
      intra-ocular layer of the central fovea were the same for each group. However, 
      the amblyopic eyes were significantly thicker than the normal control eyes in 2 
      of 4 quadrants of the peripheral retina. Exploring intra-retinal layers in these 
      two quadrants, the nasal nerve fiber layer (NFL) and inferior inner nuclear layer 
      (INL)were significantly thicker in amblyopic eyes than in control eyes (p = 0.01 
      and 0.012, respectively, by ANCOVA). CONCLUSION: The SD-OCT data revealed 
      marginal differences in some foveal layers at peripheral locations and indicated 
      that structural differences might exist between individuals with amblyopia and 
      visually normal control subjects. However, the differences were scattered and 
      represented no identifiable pattern. More studies with large samples and precise 
      locations of the retinal layers must be performed to extend the present results.
FAU - Chen, Wuhe
AU  - Chen W
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Xu, Jinling
AU  - Xu J
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Zhou, Jinjing
AU  - Zhou J
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Gu, Zhouqun
AU  - Gu Z
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Huang, Shenghai
AU  - Huang S
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Li, Heming
AU  - Li H
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Qin, Zhuoer
AU  - Qin Z
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Yu, Xinping
AU  - Yu X
AD  - School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20170322
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Amblyopia/*pathology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Nose/pathology
MH  - Prospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
PMC - PMC5362228
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/03/23 06:00
MHDA- 2017/08/23 06:00
PMCR- 2017/03/22
CRDT- 2017/03/23 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2017/03/11 00:00 [accepted]
PHST- 2017/03/23 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
PHST- 2017/03/22 00:00 [pmc-release]
AID - PONE-D-15-49205 [pii]
AID - 10.1371/journal.pone.0174537 [doi]
PST - epublish
SO  - PLoS One. 2017 Mar 22;12(3):e0174537. doi: 10.1371/journal.pone.0174537. 
      eCollection 2017.