PMID- 2832964
OWN - NLM
STAT- MEDLINE
DCOM- 19880503
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 58
IP  - 4
DP  - 1987 Dec 18
TI  - Circulating activities during constant infusion of heparin or a low molecular 
      weight derivative (enoxaparine): failure to demonstrate any circadian variations.
PG  - 1068-72
AB  - We compared in six patients successively treated with an unfractionated heparin 
      (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa 
      activity, measured in a chromogenic assay, during a 36 h constant infusion. The 
      values varied in a wider range during UHF infusion, but remained in the 
      therapeutic range except once in one patient. No circadian rhythm could be 
      demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa 
      circulating activities. In both cases, there were no significant modifications of 
      three proteins with high heparin affinity (antithrombin III, heparin cofactor II, 
      histidine-rich glycoprotein). Our results suggest that the circadian rhythm of 
      the biological activities previously observed in patients treated with constant 
      heparin infusion using clotting method is due to other factors than heparin 
      itself.
FAU - Toulon, P
AU  - Toulon P
AD  - Centre de Recherche Claude-Bernard sur les maladies vasculaires peripheriques et 
      Hopital Broussais, Paris, France.
FAU - Vitoux, J F
AU  - Vitoux JF
FAU - Leroy, C
AU  - Leroy C
FAU - Lecomte, T
AU  - Lecomte T
FAU - Roncato, M
AU  - Roncato M
FAU - Motobashi, Y
AU  - Motobashi Y
FAU - Aiach, M
AU  - Aiach M
FAU - Fiessinger, J N
AU  - Fiessinger JN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Serine Proteinase Inhibitors)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Circadian Rhythm
MH  - Factor Xa
MH  - Heparin/*administration & dosage/blood
MH  - Heparin, Low-Molecular-Weight/*administration & dosage
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Serine Proteinase Inhibitors
MH  - Vascular Diseases/blood/drug therapy
EDAT- 1987/12/18 00:00
MHDA- 1987/12/18 00:01
CRDT- 1987/12/18 00:00
PHST- 1987/12/18 00:00 [pubmed]
PHST- 1987/12/18 00:01 [medline]
PHST- 1987/12/18 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1987 Dec 18;58(4):1068-72.