PMID- 28329713
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 178
DP  - 2017 Jul
TI  - PCBs and OCPs in human milk in Eastern Siberia, Russia: Levels, temporal trends 
      and infant exposure assessment.
PG  - 239-248
LID - S0045-6535(17)30421-6 [pii]
LID - 10.1016/j.chemosphere.2017.03.058 [doi]
AB  - The aim of our study is to investigate the spatial distribution of 
      polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), 
      dichlorodiphenyltrichloroethane (p,p'-DDT) and its metabolites, alpha- and gamma-isomers 
      of hexachlorocyclohexane (HCH) in 155 samples of human milk (HM) from Eastern 
      Siberia (six towns and seven villages in Irkutsk Region, one village of the 
      Republic of Buryatia and one town in Zabaikal'sk Region, Russia), and to examine 
      the dietary and social factors influencing the human exposure to the 
      organochlorines. The median and range of the concentration of six indicator PCBs 
      in HM in 14 localities in Eastern Siberia (114 (19-655) ng g(-1) lipids 
      respectively) are similar to levels in the majority of European countries. 
      However, in one village, Onguren, the median and range of levels of six indicator 
      PCBs (1390 (300-3725) ng g(-1) lipids) were comparable to levels measured in 
      highly contaminated populations. The Lake Baikal seals are highly exposed to 
      persistent organic pollutants (POPs) and could be a potential source of PCB and 
      DDT exposure in the Onguren cohort via the consumption of the Lake Baikal seal 
      tissue. The location of food production in areas exposed to the emissions of 
      local POP sources can also significantly influence POP levels in HM samples from 
      industrialized areas. Estimated daily intakes (EDI) of HCH and HCB for infants 
      are considerably lower or close to acceptable daily intake (ADI). The EDI of 
      total DDTs and total PCBs are higher than ADI.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Mamontova, Elena A
AU  - Mamontova EA
AD  - Vinogradov Institute of Geochemistry, Siberian Branch of the Russian Academy of 
      Sciences, 664033, Favorsky Str., 1A, PO Box 421, Irkutsk, Russia. Electronic 
      address: elenam@igc.irk.ru.
FAU - Tarasova, Eugenia N
AU  - Tarasova EN
AD  - Vinogradov Institute of Geochemistry, Siberian Branch of the Russian Academy of 
      Sciences, 664033, Favorsky Str., 1A, PO Box 421, Irkutsk, Russia.
FAU - Mamontov, Alexander A
AU  - Mamontov AA
AD  - Vinogradov Institute of Geochemistry, Siberian Branch of the Russian Academy of 
      Sciences, 664033, Favorsky Str., 1A, PO Box 421, Irkutsk, Russia.
LA  - eng
PT  - Journal Article
DEP - 20170319
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - DDT/analysis/metabolism
MH  - Environmental Exposure/analysis
MH  - Europe
MH  - Female
MH  - Hexachlorobenzene/analysis
MH  - Hexachlorocyclohexane/metabolism
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis/metabolism
MH  - Infant
MH  - Milk, Human/*chemistry
MH  - Polychlorinated Biphenyls/*analysis/metabolism
MH  - Russia
MH  - Seals, Earless
MH  - Siberia
OTO - NOTNLM
OT  - Diet
OT  - Human milk
OT  - Organochlorine pesticides
OT  - PCB
EDAT- 2017/03/23 06:00
MHDA- 2017/06/01 06:00
CRDT- 2017/03/23 06:00
PHST- 2016/09/28 00:00 [received]
PHST- 2017/02/21 00:00 [revised]
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2017/03/23 06:00 [entrez]
AID - S0045-6535(17)30421-6 [pii]
AID - 10.1016/j.chemosphere.2017.03.058 [doi]
PST - ppublish
SO  - Chemosphere. 2017 Jul;178:239-248. doi: 10.1016/j.chemosphere.2017.03.058. Epub 
      2017 Mar 19.