PMID- 28329921
OWN - NLM
STAT- MEDLINE
DCOM- 20170524
LR  - 20181202
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 69
IP  - 3
DP  - 2017 Mar 25
TI  - Neuroendocrine Tumors in the Stomach, Duodenum, and Pancreas Accompanied by Novel 
      MEN1 Gene Mutation.
PG  - 181-186
LID - 10.4166/kjg.2017.69.3.181 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) syndrome is a relatively rare disease, 
      characterized by the occurrence of multiple endocrine tumors in the parathyroid 
      and pituitary glands as well as the pancreas. Here, we report a case of MEN1 with 
      neuroendocrine tumors (NETs) in the stomach, duodenum, and pancreas. A 
      53-year-old man visited our hospital to manage gastric NET. Five years prior to 
      his visit, he had undergone surgery for incidental meningioma. His brother had 
      pancreatic nodules and a history of surgery for adrenal adenoma. His brother's 
      daughter also had pancreatic nodules, but had not undergone surgery. The lesion 
      was treated by endoscopic submucosal dissection and diagnosed as a grade 1 NET. 
      Another small NET was detected in the second duodenal portion, resected by 
      endoscopic submucosal dissection, which was also diagnosed as a grade 1 NET. 
      During evaluation, three nodules were detected in the pancreas, and no evidence 
      of pituitary, parathyroid tumors, or metastasis was observed. After surgery, the 
      pancreatic lesions were diagnosed as NETs, with the same immunohistochemical 
      patterns as those of the stomach and duodenum. Genetic testing was performed, and 
      a heterozygous mutation was detected in the MEN1 gene, which is located on 11q13.
FAU - Yang, Min A
AU  - Yang MA
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Lee, Woong Ki
AU  - Lee WK
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Shin, Hong Shik
AU  - Shin HS
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Park, Sung Hyun
AU  - Park SH
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Kim, Byung Sun
AU  - Kim BS
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Kim, Ji Woong
AU  - Kim JW
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Cho, Jin Woong
AU  - Cho JW
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
FAU - Yun, So Hee
AU  - Yun SH
AD  - Division of Gastroenterology, Department of Internal Medicine, Presbyterian 
      Medical Center, Jeonju, Korea.
LA  - eng
PT  - Case Reports
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - DNA Mutational Analysis
MH  - Duodenum/diagnostic imaging/metabolism/*pathology
MH  - Gastric Mucosa/metabolism
MH  - Germ-Line Mutation
MH  - Humans
MH  - INDEL Mutation
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/genetics
MH  - Pancreas/diagnostic imaging/metabolism/*pathology
MH  - Proto-Oncogene Proteins/*genetics
MH  - Stomach/diagnostic imaging/*pathology
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Endoscopy
OT  - Germ-line mutation
OT  - INDEL mutation
OT  - Multiple endocrine neoplasia type 1
OT  - Neuroendocrine tumors
EDAT- 2017/03/23 06:00
MHDA- 2017/05/26 06:00
CRDT- 2017/03/23 06:00
PHST- 2017/03/23 06:00 [entrez]
PHST- 2017/03/23 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
AID - 10.4166kjg.2017.69.3.181 [pii]
AID - 10.4166/kjg.2017.69.3.181 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2017 Mar 25;69(3):181-186. doi: 
      10.4166/kjg.2017.69.3.181.