PMID- 28330827
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20240327
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 62
DP  - 2017 Nov
TI  - Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and 
      telomere length in the brain of adult rat offspring.
PG  - 56-62
LID - S0736-5748(16)30374-4 [pii]
LID - 10.1016/j.ijdevneu.2017.03.007 [doi]
AB  - DNA methylation (addition of methyl groups to cytosines) and changes in telomere 
      length (TTAGGG repeats on the ends of chromosomes) are two molecular 
      modifications that result from stress and could contribute to the long-term 
      effects of intrauterine exposure to maternal stress on offspring behavior. Here, 
      we measured methylation of DNA associated with the Brain-derived neurotrophic 
      factor (Bdnf) gene, a gene important in development and plasticity, and telomere 
      length in the brains of adult rat male and female offspring whose mothers were 
      exposed to unpredictable and variable stressors throughout gestation. Males 
      exposed to prenatal stress had greater methylation (Bdnf IV) in the medial 
      prefrontal cortex (mPFC) compared to non-stressed male controls and stressed 
      females. Further, prenatally-stressed animals had shorter telomeres than controls 
      in the mPFC. Together findings indicate a long-term impact of prenatal stress on 
      brain DNA methylation and telomere biology with relevance for behavioral and 
      health outcomes, and contribute to a growing literature linking stress to 
      intergenerational molecular changes.
CI  - Copyright (c) 2017 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Blaze, Jennifer
AU  - Blaze J
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE,United States.
FAU - Asok, Arun
AU  - Asok A
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE,United States.
FAU - Borrelli, Kristyn
AU  - Borrelli K
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE,United States.
FAU - Tulbert, Christina
AU  - Tulbert C
AD  - Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, 
      United States.
FAU - Bollinger, Justin
AU  - Bollinger J
AD  - Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, 
      United States.
FAU - Ronca, April E
AU  - Ronca AE
AD  - Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, 
      United States; Program in Neuroscience, Wake Forest School of Medicine, 
      Winston-Salem, NC, United States; Space Biosciences Research Division, NASA Ames 
      Research Center, Moffett Field, CA.
FAU - Roth, Tania L
AU  - Roth TL
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE,United States. Electronic address: troth@psych.udel.edu.
LA  - eng
GR  - P20 GM103446/GM/NIGMS NIH HHS/United States
GR  - P20 GM103653/GM/NIGMS NIH HHS/United States
GR  - R01 HD050201/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20170319
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - DNA Methylation/*genetics
MH  - Epigenesis, Genetic/*physiology
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Factors
MH  - *Stress, Psychological/genetics/metabolism/pathology
MH  - Telomere Homeostasis/*physiology
PMC - PMC5600826
MID - NIHMS873339
OTO - NOTNLM
OT  - DNA methylation
OT  - Maternal stress
OT  - Prenatal stress
OT  - Telomere length
EDAT- 2017/03/24 06:00
MHDA- 2018/05/16 06:00
PMCR- 2018/11/01
CRDT- 2017/03/24 06:00
PHST- 2016/12/31 00:00 [received]
PHST- 2017/03/14 00:00 [revised]
PHST- 2017/03/17 00:00 [accepted]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/03/24 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S0736-5748(16)30374-4 [pii]
AID - 10.1016/j.ijdevneu.2017.03.007 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2017 Nov;62:56-62. doi: 10.1016/j.ijdevneu.2017.03.007. Epub 
      2017 Mar 19.