PMID- 28331286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1177-5475 (Print)
IS  - 1177-5491 (Electronic)
IS  - 1177-5475 (Linking)
VI  - 11
DP  - 2017
TI  - Neutralizing activities against seasonal influenza viruses in human intravenous 
      immunoglobulin.
PG  - 23-30
LID - 10.2147/BTT.S123831 [doi]
AB  - Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo 
      annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal 
      influenza virus globulins. Although the virus-neutralizing (VN) titer is an 
      indicator of protective antibodies, changes in this titer over extended time 
      periods have yet to be examined. In this study, variations in hemagglutination 
      inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots 
      over extended time periods were examined. In addition, the importance of 
      monitoring the reactivity of IVIG against seasonal influenza viruses with varying 
      antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and 
      IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured 
      by standard methods. The VN titer was measured using a micro-focus method. IVIG 
      exhibited significant HI and VN titers against all investigated strains. Our 
      results suggest that the donor population maintains both specific and 
      cross-reactive antibodies against seasonal influenza viruses, except in cases of 
      pandemic viruses, despite major antigen changes. The titers against seasonal 
      influenza vaccine strains, including past strains, were stable over short time 
      periods but increased slowly over time.
FAU - Onodera, Hiroyuki
AU  - Onodera H
AD  - Medical Information Department.
FAU - Urayama, Takeru
AU  - Urayama T
AD  - Research and Development Division, Japan Blood Products Organization, Tokyo.
FAU - Hirota, Kazue
AU  - Hirota K
AD  - Research and Development Division, The Research Foundation for Microbial Diseases 
      of Osaka University, Kagawa.
FAU - Maeda, Kazuhiro
AU  - Maeda K
AD  - Research and Development Division, The Research Foundation for Microbial Diseases 
      of Osaka University, Kagawa.
FAU - Kubota-Koketsu, Ritsuko
AU  - Kubota-Koketsu R
AD  - Research and Development Division, The Research Foundation for Microbial Diseases 
      of Osaka University, Kagawa; Former Department of Virology, Research Institute 
      for Microbial Diseases, Osaka University.
FAU - Takahashi, Kazuo
AU  - Takahashi K
AD  - Virology Division, Department of Infectious Diseases, Osaka Prefectural Institute 
      of Public Health, Osaka.
FAU - Hagiwara, Katsuro
AU  - Hagiwara K
AD  - Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen 
      University, Hokkaido, Japan.
FAU - Okuno, Yoshinobu
AU  - Okuno Y
AD  - Research and Development Division, The Research Foundation for Microbial Diseases 
      of Osaka University, Kagawa.
FAU - Ikuta, Kazuyoshi
AU  - Ikuta K
AD  - Research and Development Division, The Research Foundation for Microbial Diseases 
      of Osaka University, Kagawa; Former Department of Virology, Research Institute 
      for Microbial Diseases, Osaka University.
FAU - Yunoki, Mikihiro
AU  - Yunoki M
AD  - Research and Development Division, Japan Blood Products Organization, Tokyo; 
      Former Department of Virology, Research Institute for Microbial Diseases, Osaka 
      University; Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, 
      Rakuno Gakuen University, Hokkaido, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170310
PL  - New Zealand
TA  - Biologics
JT  - Biologics : targets & therapy
JID - 101321511
PMC - PMC5354529
OTO - NOTNLM
OT  - IVIG
OT  - influenza
OT  - neutralization
OT  - seasonal
OT  - vaccine
COIS- Disclosure H. Onodera, T. Urayama, and M. Yunoki are employees of the Japan Blood 
      Products Organization. T. Urayama and M. Yunoki are also former employees of the 
      Benesis Corporation. H. Onodera is a former employee of the Japanese Red Cross 
      Society. K. Maeda, R. Kubota-Koketsu, K. Hirota, Y. Okuno, and K. Ikuta are 
      employees of The Research Foundation for Microbial Diseases of Osaka University. 
      K. Ikuta was also a Professor at Osaka University. K. Takahashi is currently 
      affiliated to the Department of Clinical Laboratory, International University of 
      Health and Welfare Hospital. The authors report no other conflicts of interest.
EDAT- 2017/03/24 06:00
MHDA- 2017/03/24 06:01
PMCR- 2017/03/10
CRDT- 2017/03/24 06:00
PHST- 2017/03/24 06:00 [entrez]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/03/24 06:01 [medline]
PHST- 2017/03/10 00:00 [pmc-release]
AID - btt-11-023 [pii]
AID - 10.2147/BTT.S123831 [doi]
PST - epublish
SO  - Biologics. 2017 Mar 10;11:23-30. doi: 10.2147/BTT.S123831. eCollection 2017.