PMID- 28331627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2053-8790 (Print)
IS  - 2053-8790 (Electronic)
IS  - 2053-8790 (Linking)
VI  - 4
IP  - 1
DP  - 2017
TI  - Topical drug-induced subacute cutaneous lupus erythematosus isolated to the 
      hands.
PG  - e000207
LID - 10.1136/lupus-2017-000207 [doi]
LID - e000207
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus 
      erythematosus, characterised by photosensitivity, annular and/or psoriasiform 
      lesions, variable systemic involvement and presence of circulating SSA/anti-Ro 
      antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and 
      drug-induced forms of SCLE are analogous in their clinical, serological and 
      histological features. Drug-induced SCLE has been reported with various oral 
      agents, but to our knowledge this is the first reported case due to a topical 
      medication. A 34-year-old female foot masseuse presented with a 2-month history 
      of scaly, erythematous lesions isolated to the dorsal hands and interdigital 
      spaces. She had used topical terbinafine, a topical antifungal cream, to her 
      clients' feet for a number of years. ANA and anti-SSA/Ro antibodies were 
      positive. Physical examination, serology and histopathology were consistent with 
      SCLE. We propose that our patient's unique presentation of SCLE may be explained 
      by a prolonged occupational exposure to topical terbinafine as a foot masseuse. 
      While oral terbinafine is a drug known to cause drug-induced SCLE, to our 
      knowledge, this is the first topically induced form of the disease.
FAU - Ramachandran, Sarika M
AU  - Ramachandran SM
AD  - The Ronald O. Perelman Department of Dermatology , New York University School of 
      Medicine , New York, New York , USA.
FAU - Leventhal, Jonathan S
AU  - Leventhal JS
AD  - The Ronald O. Perelman Department of Dermatology , New York University School of 
      Medicine , New York, New York , USA.
FAU - Franco, Loren G
AU  - Franco LG
AD  - The Ronald O. Perelman Department of Dermatology , New York University School of 
      Medicine , New York, New York , USA.
FAU - Mir, Adnan
AU  - Mir A
AD  - The Ronald O. Perelman Department of Dermatology , New York University School of 
      Medicine , New York, New York , USA.
FAU - Walters, Ruth F
AU  - Walters RF
AD  - The Ronald O. Perelman Department of Dermatology , New York University School of 
      Medicine , New York, New York , USA.
FAU - Franks, Andrew G Jr
AU  - Franks AG Jr
AD  - The Ronald O. Perelman Department of Dermatology, New York University School of 
      Medicine, New York, New York, USA; Division of Rheumatology, Department of 
      Medicine, New York University School of Medicine, New York, New York, USA.
LA  - eng
PT  - Case Reports
DEP - 20170313
PL  - England
TA  - Lupus Sci Med
JT  - Lupus science & medicine
JID - 101633705
PMC - PMC5353283
OTO - NOTNLM
OT  - Autoantibodies
OT  - Autoimmune Diseases
OT  - Systemic Lupus Erythematosus
COIS- Competing interests: None declared.
EDAT- 2017/03/24 06:00
MHDA- 2017/03/24 06:01
PMCR- 2017/03/13
CRDT- 2017/03/24 06:00
PHST- 2017/01/17 00:00 [received]
PHST- 2017/02/11 00:00 [revised]
PHST- 2017/02/14 00:00 [accepted]
PHST- 2017/03/24 06:00 [entrez]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/03/24 06:01 [medline]
PHST- 2017/03/13 00:00 [pmc-release]
AID - lupus-2017-000207 [pii]
AID - 10.1136/lupus-2017-000207 [doi]
PST - epublish
SO  - Lupus Sci Med. 2017 Mar 13;4(1):e000207. doi: 10.1136/lupus-2017-000207. 
      eCollection 2017.