PMID- 28332265
OWN - NLM
STAT- MEDLINE
DCOM- 20170718
LR  - 20170718
IS  - 1474-8673 (Electronic)
IS  - 1474-8665 (Linking)
VI  - 37
IP  - 1
DP  - 2017 Jan
TI  - Antidiuretic and antinatriuretic response to high salt load in normotensive 
      Wistar-Kyoto rats: Role of alpha-1A-adrenoreceptors.
PG  - 13-18
LID - 10.1111/aap.12053 [doi]
AB  - Altered renal adrenergic responses have been recognized as pathophysiological 
      responses to high salt intake. This study aims to investigate the influence of 
      6 weeks of high salt diet on alpha(1A) -adrenoceptor regulation of renal tubular 
      antinatriuretic and antidiuretic response in normal Wistar Kyoto rats. To achieve 
      the above objective, antinatriuretic and antidiuretic response to phenylephrine 
      was measured in the absence and presence of 5-methylurapidil (5-MeU) using the 
      inulin clearance method. Systemic mean arterial blood pressure and renal 
      haemodynamics were also measured simultaneously. Six weeks of high salt intake in 
      Wistar-Kyoto (WKY) rats did not bring any significant increase in mean arterial 
      blood pressure. WKY rat on high salt diet (WKYHNa) showed an exaggerated increase 
      in absolute and fractional sodium excretion. There was a significant involvement 
      of alpha(1A) -adrenoceptor in carrying out renal tubular antinatriuretic and 
      antidiuretic response in Wistar Kyoto rats on normal sodium diet (WKYNNa). 
      However, alpha(1A) -adrenoceptor played a minimal role in handling the tubular 
      reabsorptive response in WKY rats on high salt diet.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Kazi, R N
AU  - Kazi RN
AUID- ORCID: 0000-0003-4547-6427
AD  - College of Applied Medical Science, Prince Sattam Bin Abdul-Aziz University, Wadi 
      Ad Dawaser, Saudi Arabia.
AD  - School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.
FAU - Sattar, M A
AU  - Sattar MA
AD  - School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.
FAU - Johns, E J
AU  - Johns EJ
AD  - Department of Physiology, Aras Windle, University College Cork, Cork, Ireland.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Auton Autacoid Pharmacol
JT  - Autonomic & autacoid pharmacology
JID - 101157306
RN  - 0 (Antidiuretic Agents)
RN  - 0 (Insulin)
RN  - 0 (Natriuretic Agents)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 1HLS600135 (5-methylurapidil)
RN  - 1WS297W6MV (Phenylephrine)
SB  - IM
MH  - Animals
MH  - Antidiuretic Agents/*pharmacology
MH  - Arterial Pressure/drug effects
MH  - Insulin/metabolism
MH  - Male
MH  - Natriuretic Agents/*pharmacology
MH  - Phenylephrine/pharmacology
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Receptors, Adrenergic, alpha-1/*drug effects
MH  - Renal Circulation
MH  - Sodium Chloride, Dietary/*pharmacology
OTO - NOTNLM
OT  - WKY rats
OT  - antidiuresis
OT  - antinatriuresis
OT  - high salt
OT  - alpha1A-adrenoceptor
EDAT- 2017/03/24 06:00
MHDA- 2017/07/19 06:00
CRDT- 2017/03/24 06:00
PHST- 2016/10/06 00:00 [received]
PHST- 2016/12/29 00:00 [revised]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/03/24 06:00 [entrez]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/07/19 06:00 [medline]
AID - 10.1111/aap.12053 [doi]
PST - ppublish
SO  - Auton Autacoid Pharmacol. 2017 Jan;37(1):13-18. doi: 10.1111/aap.12053.