PMID- 28332559
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20180307
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 18
IP  - 2
DP  - 2017 Mar
TI  - The immunogenetics of narcolepsy associated with A(H1N1)pdm09 vaccination 
      (Pandemrix) supports a potent gene-environment interaction.
PG  - 75-81
LID - 10.1038/gene.2017.1 [doi]
AB  - The influenza A(H1N1)pdm09 vaccination campaign from 2009 to 2010 was associated 
      with a sudden increase in the incidence of narcolepsy in several countries. 
      Narcolepsy with cataplexy is strongly associated with the human leukocyte antigen 
      (HLA) class II DQB1*06:02 allele, and protective associations with the DQB1*06:03 
      allele have been reported. Several non-HLA gene loci are also associated, such as 
      common variants of the T-cell receptor-alpha (TRA), the purinergic receptor P2RY11, 
      cathepsin H (CTSH) and TNFSF4/OX40L/CD252. In this retrospective multicenter 
      study, we investigated if these predisposing gene loci were also involved in 
      vaccination-associated narcolepsy. We compared HLA- along with single-nucleotide 
      polymorphism genotypes for non-HLA regions between 42 Pandemrix-vaccinated 
      narcolepsy cases and 1990 population-based controls. The class II gene loci 
      associations supported previous findings. Nominal association (P-value<0.05) with 
      TRA as well as suggestive (P-value<0.1) associations with P2RY11 and CTSH were 
      found. These associations suggest a very strong gene-environment interaction, in 
      which the influenza A(H1N1)pdm09 strain or Pandemrix vaccine can act as potent 
      environmental triggers.
FAU - Bomfim, I L
AU  - Bomfim IL
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
FAU - Lamb, F
AU  - Lamb F
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Fink, K
AU  - Fink K
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Szakacs, A
AU  - Szakacs A
AD  - Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden.
FAU - Silveira, A
AU  - Silveira A
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
AD  - Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, 
      Solna, Sweden.
FAU - Franzen, L
AU  - Franzen L
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
FAU - Azhary, V
AU  - Azhary V
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
FAU - Maeurer, M
AU  - Maeurer M
AD  - Division of Therapeutic Immunology, Department of Laboratory Medicine, Stockholm, 
      Sweden.
AD  - Center for Allogeneic Stem Cell Transplantation (CAST), Karolinska University 
      Hospital, Stockholm, Sweden.
FAU - Feltelius, N
AU  - Feltelius N
AD  - Medical Products Agency, Uppsala, Sweden.
FAU - Darin, N
AU  - Darin N
AD  - Department of Pediatrics, Institute of Clinical Sciences, University of 
      Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
FAU - Hallbook, T
AU  - Hallbook T
AD  - Department of Pediatrics, Institute of Clinical Sciences, University of 
      Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
FAU - Arnheim-Dahlstrom, L
AU  - Arnheim-Dahlstrom L
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Kockum, I
AU  - Kockum I
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
FAU - Olsson, T
AU  - Olsson T
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
AD  - Centre for Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
AD  - Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20170323
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Influenza Vaccines)
RN  - 0 (pandemrix)
SB  - IM
MH  - *Gene-Environment Interaction
MH  - HLA-DQ beta-Chains/genetics
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype
MH  - Influenza Vaccines/*adverse effects
MH  - Narcolepsy/*chemically induced/*genetics
MH  - Retrospective Studies
EDAT- 2017/03/24 06:00
MHDA- 2017/07/25 06:00
CRDT- 2017/03/24 06:00
PHST- 2016/10/03 00:00 [received]
PHST- 2016/12/06 00:00 [revised]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2017/03/24 06:00 [entrez]
AID - gene20171 [pii]
AID - 10.1038/gene.2017.1 [doi]
PST - ppublish
SO  - Genes Immun. 2017 Mar;18(2):75-81. doi: 10.1038/gene.2017.1. Epub 2017 Mar 23.