PMID- 28333113
OWN - NLM
STAT- MEDLINE
DCOM- 20170518
LR  - 20230928
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 22
IP  - 4
DP  - 2017 Mar 23
TI  - Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of 
      Composite Scaffolds.
LID - 10.3390/molecules22040511 [doi]
LID - 511
AB  - Diopside (DIOP) was introduced into polyetheretherketone/polyglycolicacid 
      (PEEK/PGA) scaffolds fabricated via selective laser sintering to improve 
      bioactivity. The DIOP surface was then modified using a silane coupling agent, 
      3-glycidoxypropyltrimethoxysilane (KH570), to reinforce interfacial adhesion. The 
      results showed that the tensile properties and thermal stability of the scaffolds 
      were significantly enhanced. It could be explained that, on the one hand, the 
      hydrophilic group of KH570 formed an organic covalent bond with the hydroxy group 
      on DIOP surface. On the other hand, there existed relatively high compatibility 
      between its hydrophobic group and the biopolymer matrix. Thus, the ameliorated 
      interface interaction led to a homogeneous state of DIOP dispersion in the 
      matrix. More importantly, an in vitro bioactivity study demonstrated that the 
      scaffolds with KH570-modified DIOP (KDIOP) exhibited the capability of forming a 
      layer of apatite. In addition, cell culture experiments revealed that they had 
      good biocompatibility compared to the scaffolds without KDIOP. It indicated that 
      the scaffolds with KDIOP possess potential application in tissue engineering.
FAU - Shuai, Cijun
AU  - Shuai C
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. shuai@csu.edu.cn.
AD  - The State Key Laboratory for Powder Metallurgy, Central South University, 
      Changsha 410083, China. shuai@csu.edu.cn.
AD  - Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan 
      Province, Changsha 410008, China. shuai@csu.edu.cn.
AD  - State Key Laboratory of Solidification Processing, Northwestern Polytechnical 
      University, Xi'an 710072, China. shuai@csu.edu.cn.
FAU - Shuai, Chenying
AU  - Shuai C
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. shuaichenying@csu.edu.cn.
FAU - Feng, Pei
AU  - Feng P
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. fengpei@csu.edu.cn.
AD  - The State Key Laboratory for Powder Metallurgy, Central South University, 
      Changsha 410083, China. fengpei@csu.edu.cn.
FAU - Yang, Youwen
AU  - Yang Y
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. yangyouwen@csu.edu.cn.
AD  - State Key Laboratory of Solidification Processing, Northwestern Polytechnical 
      University, Xi'an 710072, China. yangyouwen@csu.edu.cn.
FAU - Xu, Yong
AU  - Xu Y
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. xuyong2927@csu.edu.cn.
FAU - Qin, Tian
AU  - Qin T
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. qintian@csu.edu.cn.
FAU - Yang, Sheng
AU  - Yang S
AD  - Human Reproduction Center, Shenzhen Hospital of Hongkong University, Shenzhen 
      518053, China. tobyys2000@aliyun.com.
FAU - Gao, Chengde
AU  - Gao C
AD  - State Key Laboratory of High Performance Complex Manufacturing, Central South 
      University, Changsha 410083, China. gaochengde@csu.edu.cn.
AD  - The State Key Laboratory for Powder Metallurgy, Central South University, 
      Changsha 410083, China. gaochengde@csu.edu.cn.
FAU - Peng, Shuping
AU  - Peng S
AD  - The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya 
      Hospital, Central South University, Changsha 410008, China. 
      gaochengde@csu.edu.cn.
AD  - The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry 
      of Education, Cancer Research Institute, Central South University, Changsha 
      410078, China. gaochengde@csu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170323
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Silanes)
RN  - 1343-98-2 (Silicic Acid)
RN  - 14483-19-3 (diopside)
SB  - IM
MH  - Cell Line
MH  - Humans
MH  - Silanes/*chemical synthesis/chemistry
MH  - Silicic Acid/*chemistry
MH  - Surface Properties
PMC - PMC6153932
OTO - NOTNLM
OT  - bioactivity
OT  - diopside
OT  - interface adhesion
OT  - scaffolds
OT  - silane coupling agent
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/24 06:00
MHDA- 2017/05/19 06:00
PMCR- 2017/03/23
CRDT- 2017/03/24 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/03/18 00:00 [revised]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/03/24 06:00 [entrez]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/05/19 06:00 [medline]
PHST- 2017/03/23 00:00 [pmc-release]
AID - molecules22040511 [pii]
AID - molecules-22-00511 [pii]
AID - 10.3390/molecules22040511 [doi]
PST - epublish
SO  - Molecules. 2017 Mar 23;22(4):511. doi: 10.3390/molecules22040511.