PMID- 28334675
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20220318
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 215
DP  - 2017 Jun
TI  - Exercise increases serum brain-derived neurotrophic factor in patients with major 
      depressive disorder.
PG  - 152-155
LID - S0165-0327(16)32060-2 [pii]
LID - 10.1016/j.jad.2017.03.034 [doi]
AB  - BACKGROUND: Brain derived neurotrophic factor (BDNF) has been implicated in the 
      pathogenesis of major depressive disorder (MDD). Existing data on exercise 
      treatment in people with MDD are inconsistent concerning the effect of exercise 
      on BDNF pointing either to increased or unaltered BDNF concentrations. However, 
      studies in non-depressed persons demonstrated a significant effect on resting 
      peripheral BDNF concentrations in aerobic training interventions. Given the lack 
      of clarity mentioned above, the current study aimed at examining the effect of 
      adjunctive exercise on serum BDNF levels in guideline based treated patients with 
      MDD. METHODS: 42 depressed inpatients were included, and randomized either to a 6 
      week structured and supervised exercise intervention plus treatment as usual 
      (EXERCISE, n=22), or to treatment as usual (TAU, n=20). BDNF serum concentrations 
      were assessed before and after the intervention in both study groups with 
      established immunoassays. RESULTS: Serum BDNF slightly decreased in the TAU 
      group, whilst there was an increase in BDNF levels in the exercise group. There 
      was a significant time x group effect concerning sBDNF (p=0.030) with repeated 
      ANOVA measures with age and BMI as covariates, suggesting an increase in BDNF 
      concentrations in the EXERCISE group compared to TAU. LIMITATIONS: Though there 
      was no statistic difference in the antidepressant medication between EXERCISE and 
      TAU potential interactions between exercise and medication on the effects of 
      exercise in BDNF cannot be excluded. Gender was not considered as a covariate in 
      ANOVA due to the small number of objects. CONCLUSIONS: Exercise training given as 
      adjunct to standard guideline based treatment appears to have additional effects 
      on BDNF serum concentrations in people with MDD. Our results add further evidence 
      to the beneficial effects of exercise in the treatment of MDD.
CI  - Crown Copyright (c) 2017. Published by Elsevier B.V. All rights reserved.
FAU - Kerling, A
AU  - Kerling A
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 
      Electronic address: kerling.arno@mh-hannover.de.
FAU - Kuck, M
AU  - Kuck M
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
FAU - Tegtbur, U
AU  - Tegtbur U
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
FAU - Grams, L
AU  - Grams L
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
FAU - Weber-Spickschen, S
AU  - Weber-Spickschen S
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
FAU - Hanke, A
AU  - Hanke A
AD  - Institute of Sports Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
FAU - Stubbs, B
AU  - Stubbs B
AD  - Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark 
      Hill, SE5 8AZ London, United Kingdom; Health Service and Population Research 
      Department, Institute of Psychiatry, King's College London,London, United 
      Kingdom.
FAU - Kahl, K G
AU  - Kahl KG
AD  - Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical 
      School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170318
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/blood/*therapy
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Inpatients/psychology
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Young Adult
OTO - NOTNLM
OT  - Aerobic exercise
OT  - BDNF
OT  - Exercise intervention
OT  - Major depressive disorder
EDAT- 2017/03/24 06:00
MHDA- 2017/07/04 06:00
CRDT- 2017/03/24 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/01/31 00:00 [revised]
PHST- 2017/03/10 00:00 [accepted]
PHST- 2017/03/24 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
PHST- 2017/03/24 06:00 [entrez]
AID - S0165-0327(16)32060-2 [pii]
AID - 10.1016/j.jad.2017.03.034 [doi]
PST - ppublish
SO  - J Affect Disord. 2017 Jun;215:152-155. doi: 10.1016/j.jad.2017.03.034. Epub 2017 
      Mar 18.