PMID- 28335194
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 6
IP  - 4
DP  - 2016 Apr 11
TI  - Automatic Echographic Detection of Halloysite Clay Nanotubes in a Low 
      Concentration Range.
LID - 10.3390/nano6040066 [doi]
LID - 66
AB  - Aim of this work was to investigate the automatic echographic detection of an 
      experimental drug delivery agent, halloysite clay nanotubes (HNTs), by employing 
      an innovative method based on advanced spectral analysis of the corresponding 
      "raw" radiofrequency backscatter signals. Different HNT concentrations in a low 
      range (5.5-66 x 10(10) part/mL, equivalent to 0.25-3.00 mg/mL) were dispersed in 
      custom-designed tissue-mimicking phantoms and imaged through a 
      clinically-available echographic device at a conventional ultrasound diagnostic 
      frequency (10 MHz). The most effective response (sensitivity = 60%, specificity = 
      95%), was found at a concentration of 33 x 10(10) part/mL (1.5 mg/mL), 
      representing a kind of best compromise between the need of enough particles to 
      introduce detectable spectral modifications in the backscattered signal and the 
      necessity to avoid the losses of spectral peculiarity associated to higher HNT 
      concentrations. Based on theoretical considerations and quantitative comparisons 
      with literature-available results, this concentration could also represent an 
      optimal concentration level for the automatic echographic detection of different 
      solid nanoparticles when employing a similar ultrasound frequency. Future 
      dedicated studies will assess the actual clinical usefulness of the proposed 
      approach and the potential of HNTs for effective theranostic applications.
FAU - Conversano, Francesco
AU  - Conversano F
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      conversano@ifc.cnr.it.
FAU - Pisani, Paola
AU  - Pisani P
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      pisanip@ifc.cnr.it.
FAU - Casciaro, Ernesto
AU  - Casciaro E
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      ernesto.casciaro@ifc.cnr.it.
FAU - Di Paola, Marco
AU  - Di Paola M
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      m.dipaola@ifc.cnr.it.
FAU - Leporatti, Stefano
AU  - Leporatti S
AD  - National Research Council, Institute of Nanotechnology, Lecce 73100, Italy. 
      stefano.leporatti@nanotec.cnr.it.
FAU - Franchini, Roberto
AU  - Franchini R
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      rfranchini@ifc.cnr.it.
FAU - Quarta, Alessandra
AU  - Quarta A
AD  - National Research Council, Institute of Nanotechnology, Lecce 73100, Italy. 
      alessandra.quarta@nanotec.cnr.it.
FAU - Gigli, Giuseppe
AU  - Gigli G
AD  - National Research Council, Institute of Nanotechnology, Lecce 73100, Italy. 
      giuseppe.gigli@nanotec.cnr.it.
FAU - Casciaro, Sergio
AU  - Casciaro S
AD  - National Research Council, Institute of Clinical Physiology, Lecce 73100, Italy. 
      sergio.casciaro@cnr.it.
LA  - eng
PT  - Journal Article
DEP - 20160411
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC5302578
OTO - NOTNLM
OT  - automatic nanoparticle detection
OT  - automatic tissue typing
OT  - cell targeting
OT  - halloysite clay nanotubes
OT  - nanoimaging
OT  - ultrasound contrast agents
COIS- The authors declare no conflict of interest.
EDAT- 2016/01/01 00:00
MHDA- 2016/01/01 00:01
PMCR- 2016/04/11
CRDT- 2017/03/25 06:00
PHST- 2016/03/06 00:00 [received]
PHST- 2016/04/01 00:00 [revised]
PHST- 2016/04/05 00:00 [accepted]
PHST- 2017/03/25 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2016/01/01 00:01 [medline]
PHST- 2016/04/11 00:00 [pmc-release]
AID - nano6040066 [pii]
AID - nanomaterials-06-00066 [pii]
AID - 10.3390/nano6040066 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2016 Apr 11;6(4):66. doi: 10.3390/nano6040066.