PMID- 28335419
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20181113
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 15
IP  - 3
DP  - 2017 Mar 14
TI  - Anti-Allergic Compounds from the Deep-Sea-Derived Actinomycete Nesterenkonia 
      flava MCCC 1K00610.
LID - 10.3390/md15030071 [doi]
LID - 71
AB  - A novel cyclic ether, nesterenkoniane (1), was isolated from the deep-sea-derived 
      actinomycete Nesterenkonia flava MCCC 1K00610, together with 12 known compounds, 
      including two macrolides (2, 3), two diketopiperazines (4, 5), two nucleosides 
      (6, 7), two indoles (8, 9), three phenolics (10-12), and one butanol derivate 
      (13). Their structures were established mainly on detailed analysis of the NMR 
      and MS spectroscopic data. All 13 compounds were tested for anti-allergic 
      activities using immunoglobulin E (IgE) mediated rat mast RBL-2H3 cell model. 
      Under the concentration of 20 mug/mL, 1 exhibited moderate anti-allergic activity 
      with inhibition rate of 9.86%, compared to that of 37.41% of the positive 
      control, loratadine. While cyclo(d)-Pro-(d)-Leu (4) and indol-3-carbaldehyde (8) 
      showed the most potent effects with the IC(50) values of 69.95 and 57.12 mug/mL, 
      respectively, which was comparable to that of loratadine (IC(50) = 35.01 mug/mL). 
      To the best of our knowledge, it is the first report on secondary metabolites 
      from the genus of Nesterenkonia.
FAU - Xie, Chun-Lan
AU  - Xie CL
AD  - State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of 
      Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, 
      Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, 
      Xiamen 361005, China. xiechunlanxx@163.com.
AD  - Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 
      Guangzhou 510006, China. xiechunlanxx@163.com.
FAU - Liu, Qingmei
AU  - Liu Q
AD  - College of Food and Biological Engineering, Jimei University, 43 Yindou Road, 
      Xiamen 36102, China. liuqingmei1229@163.com.
FAU - Xia, Jin-Mei
AU  - Xia JM
AD  - State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of 
      Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, 
      Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, 
      Xiamen 361005, China. xiajinmei@tio.org.cn.
FAU - Gao, Yuanyuan
AU  - Gao Y
AD  - College of Food and Biological Engineering, Jimei University, 43 Yindou Road, 
      Xiamen 36102, China. yuanyuan201736@163.com.
FAU - Yang, Quan
AU  - Yang Q
AD  - Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 
      Guangzhou 510006, China. yangquan7208@vip.163.com.
FAU - Shao, Zong-Ze
AU  - Shao ZZ
AD  - State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of 
      Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, 
      Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, 
      Xiamen 361005, China. shaozongze@tio.org.cn.
FAU - Liu, Guangming
AU  - Liu G
AD  - College of Food and Biological Engineering, Jimei University, 43 Yindou Road, 
      Xiamen 36102, China. gmliu@jmu.edu.cn.
FAU - Yang, Xian-Wen
AU  - Yang XW
AD  - State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of 
      Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, 
      Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, 
      Xiamen 361005, China. yangxianwen@tio.org.cn.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Butanols)
RN  - 0 (Diketopiperazines)
RN  - 0 (Indoles)
RN  - 0 (Macrolides)
RN  - 0 (Nucleosides)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7AJO3BO7QN (Loratadine)
SB  - IM
MH  - Actinobacteria/*chemistry/*metabolism
MH  - Animals
MH  - Anti-Allergic Agents/*chemistry/*pharmacology
MH  - Butanols/chemistry/pharmacology
MH  - Cell Line
MH  - Diketopiperazines/chemistry/pharmacology
MH  - Immunoglobulin E/metabolism
MH  - Indoles/chemistry/pharmacology
MH  - Loratadine/pharmacology
MH  - Macrolides/chemistry/pharmacology
MH  - Mast Cells/drug effects
MH  - Micrococcaceae/*chemistry/*metabolism
MH  - Nucleosides/chemistry/pharmacology
MH  - Rats
PMC - PMC5367028
OTO - NOTNLM
OT  - Nesterenkonia
OT  - actinomycetes
OT  - deep-sea
OT  - food allergy
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/25 06:00
MHDA- 2017/06/27 06:00
PMCR- 2017/03/01
CRDT- 2017/03/25 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/03/10 00:00 [accepted]
PHST- 2017/03/25 06:00 [entrez]
PHST- 2017/03/25 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - md15030071 [pii]
AID - marinedrugs-15-00071 [pii]
AID - 10.3390/md15030071 [doi]
PST - epublish
SO  - Mar Drugs. 2017 Mar 14;15(3):71. doi: 10.3390/md15030071.