PMID- 28337463
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20181202
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Skin Tissue Engineering: Application of Adipose-Derived Stem Cells.
PG  - 9747010
LID - 10.1155/2017/9747010 [doi]
LID - 9747010
AB  - Perception of the adipose tissue has changed dramatically over the last few 
      decades. Identification of adipose-derived stem cells (ASCs) ultimately 
      transformed paradigm of this tissue from a passive energy depot into a promising 
      stem cell source with properties of self-renewal and multipotential 
      differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are 
      more easily accessible and their isolation yields higher amount of stem cells. 
      Therefore, the ASCs are of high interest for stem cell-based therapies and skin 
      tissue engineering. Currently, freshly isolated stromal vascular fraction (SVF), 
      which may be used directly without any expansion, was also assessed to be highly 
      effective in treating skin radiation injuries, burns, or nonhealing wounds such 
      as diabetic ulcers. In this paper, we review the characteristics of SVF and ASCs 
      and the efficacy of their treatment for skin injuries and disorders.
FAU - Klar, Agnes S
AU  - Klar AS
AUID- ORCID: 0000-0003-3521-8010
AD  - University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, 
      Switzerland; Children's Research Center, University Children's Hospital Zurich, 
      Zurich, Switzerland.
FAU - Zimoch, Jakub
AU  - Zimoch J
AD  - University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, 
      Switzerland; Children's Research Center, University Children's Hospital Zurich, 
      Zurich, Switzerland.
FAU - Biedermann, Thomas
AU  - Biedermann T
AD  - University Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, 
      Switzerland; Children's Research Center, University Children's Hospital Zurich, 
      Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170227
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adipocytes/cytology
MH  - Adipose Tissue/cytology/*growth & development
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation/genetics
MH  - Humans
MH  - *Mesenchymal Stem Cells
MH  - Skin/cytology/*growth & development
MH  - Stem Cell Transplantation
MH  - *Tissue Engineering
PMC - PMC5350314
COIS- The authors declare that there is no conflict of interests regarding the 
      publication of this paper.
EDAT- 2017/03/25 06:00
MHDA- 2017/04/30 06:00
PMCR- 2017/02/27
CRDT- 2017/03/25 06:00
PHST- 2016/06/14 00:00 [received]
PHST- 2016/10/23 00:00 [revised]
PHST- 2016/10/30 00:00 [accepted]
PHST- 2017/03/25 06:00 [entrez]
PHST- 2017/03/25 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/02/27 00:00 [pmc-release]
AID - 10.1155/2017/9747010 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:9747010. doi: 10.1155/2017/9747010. Epub 2017 Feb 27.