PMID- 28337851
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20190409
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 21
IP  - 11
DP  - 2018 Nov
TI  - Low prevalence of knee chondrocalcinosis and its catabolic association with serum 
      matrix metalloproteinase 3: A rural Japanese population study.
PG  - 2011-2018
LID - 10.1111/1756-185X.13067 [doi]
AB  - AIM: This study aimed to elucidate the prevalence of radiographic knee 
      chondrocalcinosis (CC) and to clarify whether CC is correlated with self-reported 
      knee symptoms and a serum catabolic biomarker. METHODS: A total of 1278 
      volunteers participated. Plain radiographs of both knees were obtained. 
      Identification of a linear calcification in the knee joint space was defined as 
      CC. Patients with a Kellgren-Lawrence grade of 2 or more were considered to have 
      knee osteoarthritis (OA). Symptoms were evaluated using the Knee injury and 
      Osteoarthritis Outcome Score (KOOS) Pain scale, and serum matrix 
      metalloproteinase-3 (MMP-3) concentration was determined. Multiple regression 
      analysis was conducted to determine whether CC was correlated with OA, the KOOS 
      Pain scale and MMP-3 concentration. RESULTS: Twenty-eight subjects were found to 
      have CC (2.2%), and 389 had OA (30.4%). CC was correlated with OA (odds ratio: 
      5.797; P = 0.006). Additionally, CC was correlated with MMP-3 concentration (B = 
      11.415, beta = 0.059, P = 0.014), but not with KOOS Pain scale. CONCLUSIONS: The 
      prevalence of CC was low in the Japanese population evaluated in this study. 
      While CC was not correlated with self-reported knee symptoms, it was positively 
      correlated with serum MMP-3 concentration.
CI  - (c) 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Chiba, Daisuke
AU  - Chiba D
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Aomori, Japan.
FAU - Tsuda, Eiichi
AU  - Tsuda E
AD  - Department of Rehabilitation Medicine, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Aomori, Japan.
FAU - Sasaki, Eiji
AU  - Sasaki E
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Aomori, Japan.
FAU - Takahashi, Ippei
AU  - Takahashi I
AD  - Department of Social Medicine, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Aomori, Japan.
FAU - Nakaji, Shigeyuki
AU  - Nakaji S
AD  - Department of Social Medicine, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Aomori, Japan.
FAU - Ishibashi, Yasuyuki
AU  - Ishibashi Y
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Aomori, Japan.
LA  - eng
GR  - 18200044/Ministry of Education, Culture, Sports, Science and Technology of Japan/
GR  - 21500676/Japanese Society for the Promotion of Science/
GR  - 5310139302/Karoji Memorial Fund for Medical Research/
GR  - JOA-Subsidized Science Project Research from the Japanese Orthopaedic 
      Association/
PT  - Journal Article
DEP - 20170324
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Chondrocalcinosis/blood/diagnostic imaging/*enzymology/*epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Knee Joint/diagnostic imaging/*enzymology
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoarthritis/blood/diagnostic imaging/*enzymology/*epidemiology
MH  - Pain Measurement
MH  - Prevalence
MH  - *Rural Health
MH  - Self Report
OTO - NOTNLM
OT  - epidemiology
OT  - knee chondrocalcinosis
OT  - knee osteoarthritis
OT  - matrix metalloproteinase-3
OT  - symptom
EDAT- 2017/03/25 06:00
MHDA- 2019/04/10 06:00
CRDT- 2017/03/25 06:00
PHST- 2017/03/25 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
PHST- 2017/03/25 06:00 [entrez]
AID - 10.1111/1756-185X.13067 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2018 Nov;21(11):2011-2018. doi: 10.1111/1756-185X.13067. Epub 
      2017 Mar 24.