PMID- 28338529
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20170501
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 38
IP  - 5
DP  - 2017 May
TI  - Dosimetry software Hermes Internal Radiation Dosimetry: from quantitative image 
      reconstruction to voxel-level absorbed dose distribution.
PG  - 357-365
LID - 10.1097/MNM.0000000000000662 [doi]
AB  - OBJECTIVE: The aim of this work is to validate a software package called Hermes 
      Internal Radiation Dosimetry (HIRD) for internal dose assessment tailored for 
      clinical practice. The software includes all the necessary steps to perform 
      voxel-level absorbed dose calculations including quantitative reconstruction, 
      image coregistration and volume of interest tools. METHODS: The basics of 
      voxel-level dosimetry methods and implementations to HIRD software are reviewed. 
      Then, HIRD is validated using simulated SPECT/CT data and data from 
      Lu-DOTATATE-treated patients by comparing absorbed kidney doses with 
      OLINDA/EXM-based dosimetry. In addition, electron and photon dose components are 
      studied separately in an example patient case. RESULTS: The simulation study 
      showed that HIRD can reproduce time-activity curves accurately and produce 
      absorbed doses with less than 10% error for the kidneys, liver and spleen. From 
      the patient data, the absorbed kidney doses calculated using HIRD and using 
      OLINDA/EXM were highly correlated (Pearson's correlation coefficient, r=0.98). 
      From Bland-Altman plot analysis, an average absorbed dose difference of -2% was 
      found between the methods. In addition, we found that in Lu-DOTATATE-treated 
      patients, photons can contribute over 10% of the kidney's total dose and is 
      partly because of cross-irradiation from high-uptake lesions close to the 
      kidneys. CONCLUSION: HIRD is a straightforward voxel-level internal dosimetry 
      software. Its clinical utility was verified with simulated and clinical 
      Lu-DOTATATE-treated patient data. Patient studies also showed that photon 
      contribution towards the total dose can be relatively high and voxel-level dose 
      calculations can be valuable in cases where the target organ is in close 
      proximity to high-uptake organs.
FAU - Hippelainen, Eero T
AU  - Hippelainen ET
AD  - aClinical Research Institute HUCH Ltd bDepartment of Physics, University of 
      Helsinki cHUS Medical Imaging Center, Clinical Physiology and Nuclear Medicine, 
      University of Helsinki and Helsinki University Hospital dDepartment of Oncology, 
      Cancer Centre, Helsinki University Central Hospital, Helsinki eJoint Authority 
      for Paijat-Hame Social and Health Care, Department of Clinical Physiology and 
      Nuclear Medicine, Lahti, Finland fHERMES Medical Solutions, Stockholm, Sweden.
FAU - Tenhunen, Mikko J
AU  - Tenhunen MJ
FAU - Maenpaa, Hanna O
AU  - Maenpaa HO
FAU - Heikkonen, Jorma J
AU  - Heikkonen JJ
FAU - Sohlberg, Antti O
AU  - Sohlberg AO
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
SB  - IM
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Kidney/diagnostic imaging
MH  - Phantoms, Imaging
MH  - *Radiation Dosage
MH  - Radiometry/*methods
MH  - Retrospective Studies
MH  - Single Photon Emission Computed Tomography Computed Tomography
MH  - *Software
EDAT- 2017/03/25 06:00
MHDA- 2017/05/02 06:00
CRDT- 2017/03/25 06:00
PHST- 2017/03/25 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
PHST- 2017/03/25 06:00 [entrez]
AID - 10.1097/MNM.0000000000000662 [doi]
PST - ppublish
SO  - Nucl Med Commun. 2017 May;38(5):357-365. doi: 10.1097/MNM.0000000000000662.