PMID- 28340805
OWN - NLM
STAT- MEDLINE
DCOM- 20170529
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 49
IP  - 3
DP  - 2017 Apr
TI  - Association Between HLA Antibodies and Different Sensitization Events in Renal 
      Transplant Candidates.
PG  - 425-429
LID - S0041-1345(17)30130-6 [pii]
LID - 10.1016/j.transproceed.2017.02.004 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) allo-immunization is caused by various 
      events such as blood transfusions, pregnancies, or organ transplantations, which 
      can lead to sensitization. In this retrospective study, we evaluated different 
      sensitization models and their effects on panel-reactive antibody (PRA) profiles 
      of renal transplantation candidates. METHODS: Anti-HLA class I/II antibody 
      screening tests were performed in 906 renal transplantation candidates with the 
      use of a microbead-based assay (Luminex). RESULTS: Two hundred ninety-seven 
      (32.8%) of the patients were determined as positive in terms of PRA, and 609 
      (67.2%) were negative. Sensitized and non-sensitized patients were compared 
      separately in terms of each sensitization type. The anti-HLA class I, II, and 
      I+II positivity rates in patients sensitized only by blood transfusion were 
      13.1%, 6.3%, and 14.1%, the rates with pregnancy sensitization were 35.5%, 29%, 
      and 45.2%, and rates with previous transplantation sensitization were 15.6%, 
      34.4%, and 38.9%, respectively. Prevalence of PRA positivity was significantly 
      higher in patients with previous pregnancy than with transplantation and 
      transfusion (odds ratio, 1.003; 95% confidence interval, 0.441-2.281; P = .031). 
      The risk of developing HLA class I antibodies was higher in pregnancies (P < 
      .001), and the risk of developing anti-HLA class II antibodies was higher in 
      patients who had undergone a previous transplantation (P < .001). The rate of 
      developing HLA-B antibodies in patients sensitized by pregnancy were 
      significantly higher compared with sensitization after transfusion (P = .015), as 
      was the rate of developing HLA-DQ antibodies in patients sensitized by previous 
      transplantation compared with sensitization through pregnancy (P = .042). 
      CONCLUSIONS: In patients who are waiting for kidney transplantation, 
      sensitization by pregnancy and transplantation have a significant impact on 
      development of HLA class I and class II antibodies.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Akgul, S U
AU  - Akgul SU
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey. Electronic address: sebahatakgul@gmail.com.
FAU - Ciftci, H S
AU  - Ciftci HS
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Temurhan, S
AU  - Temurhan S
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Caliskan, Y
AU  - Caliskan Y
AD  - Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Bayraktar, A
AU  - Bayraktar A
AD  - Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Tefik, T
AU  - Tefik T
AD  - Department of Urology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Kaya, I A
AU  - Kaya IA
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Canitez, I O
AU  - Canitez IO
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Demir, E
AU  - Demir E
AD  - Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Yazici, H
AU  - Yazici H
AD  - Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Bakkaloglu, H
AU  - Bakkaloglu H
AD  - Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Aydin, A E
AU  - Aydin AE
AD  - Department of General Surgery, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Turkmen, A
AU  - Turkmen A
AD  - Department of Nephrology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Nane, I
AU  - Nane I
AD  - Department of Urology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Aydin, F
AU  - Aydin F
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
FAU - Oguz, F S
AU  - Oguz FS
AD  - Department of Medical Biology, Istanbul University, Istanbul Faculty of Medicine, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Autoantibodies)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - *Autoantibodies
MH  - *Blood Transfusion
MH  - Female
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Immunization
MH  - Immunologic Tests
MH  - Kidney Failure, Chronic/surgery
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Pregnancy/*immunology
MH  - Retrospective Studies
MH  - *Transplantation Immunology
EDAT- 2017/03/28 06:00
MHDA- 2017/05/30 06:00
CRDT- 2017/03/26 06:00
PHST- 2017/03/26 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/05/30 06:00 [medline]
AID - S0041-1345(17)30130-6 [pii]
AID - 10.1016/j.transproceed.2017.02.004 [doi]
PST - ppublish
SO  - Transplant Proc. 2017 Apr;49(3):425-429. doi: 10.1016/j.transproceed.2017.02.004.