PMID- 28340828
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 49
IP  - 3
DP  - 2017 Apr
TI  - Prevalence and Risk Factors of BK Viremia in Patients With Kidney 
      Transplantation: A Single-Center Experience From Turkey.
PG  - 532-536
LID - S0041-1345(17)30017-9 [pii]
LID - 10.1016/j.transproceed.2017.01.009 [doi]
AB  - BACKGROUND: BK virus is the cause of nephropathy, which can progress to graft 
      loss after kidney transplantation. In this study, we aimed to investigate the 
      prevalence and risk factors of BK viremia in patients with kidney transplantation 
      at our center. METHODS: This was a retrospective single-center study. We included 
      recipients transplanted between 2010 and 2015. Patients were stratified according 
      to BK virus DNA follow-up values into three groups (0-999 copies/mL, 1000-9999 
      copies/mL and >/=10,000 copies/mL). The parametric t test and the non-parametric 
      chi(2) test were used to detect differences between groups. Multivariate analysis 
      was used to identify risk factors for BK viremia. RESULTS: One hundred 
      eighty-three patients were included in the study, with mean follow-up time of 
      33.6 +/- 14.9 months. BK viremia prevalence was found 15.8% (n = 29), and time to 
      detection of viremia was 7.6 months. Cadaveric transplantation and matching human 
      leukocyte antigen (HLA) A24 and HLA B55 subgroups were found to be independent 
      risk factors for BK viremia [odds ratio (OR), 3.65; 95% confidence interval (CI), 
      1.42-9.39; P < .001; OR, 4.94; 95% CI, 1.84-13.2; P < .001 and OR, 14.03; 95% CI, 
      1.07-183.5; P = .04, respectively]. Risk factors for BKV level >/=10,000 copies/mL 
      cadaveric transplantation, male sex, and HLA A24 matching (OR, 4.53; 95% CI, 
      1.49-13.7; P < .001; OR, 3.47; 95% CI, 1.11-10.86; P = .03 and OR, 3.63; 95% CI, 
      1.08-12.1; P = .03, respectively). CONCLUSIONS: Patients should be followed more 
      carefully for BK viremia who have cadaveric transplantation, are male, and have 
      matching in certain HLA groups, which were independent risk factors in the 
      present study. Our results are important to individualize screening methods and 
      provide early diagnosis in our country.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Dogan, S E
AU  - Dogan SE
AD  - Ankara University School of Medicine, Department of Internal Medicine, Ankara, 
      Turkey. Electronic address: serifeezgidogan@gmail.com.
FAU - Celebi, Z K
AU  - Celebi ZK
AD  - Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey.
FAU - Akturk, S
AU  - Akturk S
AD  - Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey.
FAU - Kutlay, S
AU  - Kutlay S
AD  - Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey.
FAU - Tuzuner, A
AU  - Tuzuner A
AD  - Ankara University School of Medicine, Department of General Surgery, Ankara, 
      Turkey; Ankara University School of Medicine, Transplantation Center, Ankara, 
      Turkey.
FAU - Keven, K
AU  - Keven K
AD  - Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey; 
      Ankara University School of Medicine, Transplantation Center, Ankara, Turkey.
FAU - Sengul, S
AU  - Sengul S
AD  - Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey; 
      Ankara University School of Medicine, Transplantation Center, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - BK Virus/*isolation & purification
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Kidney Diseases/diagnosis
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Polyomavirus Infections/*etiology
MH  - Postoperative Complications/virology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transplantation, Homologous
MH  - Tumor Virus Infections/*etiology
MH  - Turkey
MH  - Viremia/diagnosis/*etiology
EDAT- 2017/03/28 06:00
MHDA- 2017/06/01 06:00
CRDT- 2017/03/26 06:00
PHST- 2017/03/26 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
AID - S0041-1345(17)30017-9 [pii]
AID - 10.1016/j.transproceed.2017.01.009 [doi]
PST - ppublish
SO  - Transplant Proc. 2017 Apr;49(3):532-536. doi: 10.1016/j.transproceed.2017.01.009.