PMID- 28340964
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20220408
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 31
IP  - 1
DP  - 2017 Jan
TI  - Higher parity is associated with increased risk of Type 2 diabetes mellitus in 
      women: A linear dose-response meta-analysis of cohort studies.
PG  - 58-66
LID - S1056-8727(16)30669-9 [pii]
LID - 10.1016/j.jdiacomp.2016.10.005 [doi]
AB  - AIM: The goal of this study is to investigate the association between higher 
      parity and the risk of occurrence of type 2 diabetes mellitus (T2DM) in women and 
      to quantify the potential dose-response relation. METHODS: We searched MEDLINE, 
      and EMBASE electronic databases for related cohort studies up to March 10th, 
      2016. Summary rate ratios (RRs) and 95% confidence intervals (CIs) for T2DM with 
      at least 3 categories of exposure were eligible. A random-effects dose-response 
      analysis procedure was used to study the relations between them. RESULTS: After 
      screening a total of 13,647 published studies, only 7 cohort studies (9,394 
      incident cases and 286,840 female participants) were found to be eligible for 
      this meta-analysis. In the category analysis, the pooled RR for the highest 
      number of parity vs. the lowest one was 1.42 (95% CI: 1.17-1.72, I(2)=71.5%, 
      P(heterogeneity)=0.002, Power=0.99). In the dose-response analysis, a noticeable 
      linear dose-risk relation was found between parity and T2DM (P(for nonlinearity 
      test)=0.942). For every live birth increase in parity, the combined RR was 1.06 
      (95% CI: 1.02-1.09, I(2)=84.3%, P(heterogeneity)=0.003, Power=0.99). Subgroup and 
      sensitivity analyses yielded similar results. No publication bias was found in 
      the results. CONCLUSION: This meta-analysis suggests that higher parity and the 
      risk of T2DM show a linear relationship in women.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Guo, Peng
AU  - Guo P
AD  - Department of Hepatobiliary Surgery, Renmin Hospital, Hubei University of 
      Medicine, Hubei 442000, China. Electronic address: guop_doc@163.com.
FAU - Zhou, Quan
AU  - Zhou Q
AD  - Department of Science and Education, The First People's Hospital of Changde City, 
      Hunan, 415003, China.
FAU - Ren, Lei
AU  - Ren L
AD  - Department of Joint Surgery, The Third Affiliated Hospital of Zunyi Medical 
      University, Zunyi 563000, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Spinal Surgery, The Third Affiliated Hospital of Zunyi Medical 
      University, Zunyi 563000, China.
FAU - Hui, Yue
AU  - Hui Y
AD  - Department of Intensive Care Unit, Taihe Hospital, Hubei University of Medicine, 
      Hubei, 442000, China. Electronic address: dfhy520115@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20161008
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Parity/*physiology
MH  - Pregnancy
MH  - Reproductive History
MH  - Risk Factors
OTO - NOTNLM
OT  - Cohort studies
OT  - Dose-response
OT  - Meta-analysis
OT  - Parity
OT  - Type 2 diabetes mellitus
EDAT- 2017/03/28 06:00
MHDA- 2018/02/15 06:00
CRDT- 2017/03/26 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2016/08/13 00:00 [revised]
PHST- 2016/10/04 00:00 [accepted]
PHST- 2017/03/26 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
AID - S1056-8727(16)30669-9 [pii]
AID - 10.1016/j.jdiacomp.2016.10.005 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2017 Jan;31(1):58-66. doi: 
      10.1016/j.jdiacomp.2016.10.005. Epub 2016 Oct 8.