PMID- 2834128
OWN - NLM
STAT- MEDLINE
DCOM- 19880608
LR  - 20191022
IS  - 0262-0898 (Print)
IS  - 0262-0898 (Linking)
VI  - 6
IP  - 4
DP  - 1988 Jul-Aug
TI  - Correlation between tumour antigens and malignancy in BKV-transformed hamster 
      cells.
PG  - 325-32
AB  - Hamster kidney cells transformed by BK virus (HKBK cells) were studied in order 
      to correlate the membrane tumour antigens to the metastatic capability. The 
      presence of the tumour associated surface antigen (TASA) on the surface of HKBK 
      cells was detected by the immunofluorescence test on live cell suspensions. The 
      metastatic ability was investigated by inoculating HKBK cells subcutaneously 
      (s.c.) into newborn hamsters, s.c., intraperitoneally (i.p.) and in the foot pads 
      into adult hamsters, and s.c. into adult hamsters previously immunized with 
      surface antigens extracted from HKBK cells. The results indicate that there is a 
      correlation between the appearance of tumour antigens on the cell surface and the 
      metastatic ability: HKBK cells at low passage (about 30 subcultures after 
      transformation) showed the capping of TASA in the cell membrane and low 
      metastatic ability, whereas HKBK cells at high passage (about 130 subcultures 
      after transformation) exhibited a diffuse appearance of TASA in the cell surface 
      and were highly metastatic.
FAU - Rosciani, C
AU  - Rosciani C
AD  - Institute of Experimental Pathology, University of Ancona, Italy.
FAU - Rubini, C
AU  - Rubini C
FAU - Possati, L
AU  - Possati L
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Exp Metastasis
JT  - Clinical & experimental metastasis
JID - 8409970
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Antigens, Neoplasm/*analysis
MH  - BK Virus/*genetics
MH  - Cell Line
MH  - Cell Line, Transformed
MH  - *Cell Transformation, Neoplastic
MH  - Cricetinae
MH  - Female
MH  - Kidney
MH  - Male
MH  - Mesocricetus
MH  - Neoplasm Metastasis/*pathology
MH  - Neoplasms, Experimental/pathology
MH  - Polyomavirus/*genetics
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 10.1007/BF01753579 [doi]
PST - ppublish
SO  - Clin Exp Metastasis. 1988 Jul-Aug;6(4):325-32. doi: 10.1007/BF01753579.