PMID- 28341881
OWN - NLM
STAT- MEDLINE
DCOM- 20171009
LR  - 20181113
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 37
IP  - 5
DP  - 2017 May
TI  - Birmingham vasculitis activity score at diagnosis is a significant predictor of 
      relapse of polyarteritis nodosa.
PG  - 685-694
LID - 10.1007/s00296-017-3706-5 [doi]
AB  - The objective of this study was to investigate whether clinical and laboratory 
      data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at 
      diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) 
      having the follow-up duration for over 12 months. We reviewed the medical charts 
      of 30 patients with PAN. We obtained clinical and laboratory data at diagnosis, 
      and we compared them between the two groups based on relapse. The optimal cut-off 
      values of BVAS and FFS (1996) at diagnosis to predict relapse were extrapolated. 
      The mean age of patients (15 men) was 50.8 years, and the mean follow-up duration 
      was 64.1 months. Nine patients (30.0%) had experience relapse after remission. 
      Patients having relapse showed the higher frequency of weight loss and ocular 
      symptoms and the less frequency of diastolic hypertension than those having not 
      (p < 0.005 for all). On multivariate logistic regression analysis, weight loss 
      was the only independent predictor of relapse, but on Cox Hazard model analysis, 
      its statistical significance disappeared. The mean initial BVAS and FFS (1996) of 
      patients in relapse group were higher than those of patients in no relapse group 
      (p < 0.005 for all). Patients having initial BVAS over 13.5 and FFS (1996) over 1 
      exhibited significantly higher risk of relapse than those having not (RR 40.0 and 
      RR 7.0, respectively). However, initial BVAS over 13.5 only remained significant 
      in Kaplan-Meier survival analysis. In conclusion, BVAS over 13.5 at diagnosis was 
      the only independent predictor of relapse of PAN.
FAU - Oh, Yoon-Jeong
AU  - Oh YJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Park, Eun Seong
AU  - Park ES
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Jung, Seung Min
AU  - Jung SM
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea. 
      sangwonlee@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20170324
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polyarteritis Nodosa/*diagnosis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recurrence
MH  - Severity of Illness Index
MH  - Vasculitis/*diagnosis
OTO - NOTNLM
OT  - Birmingham vasculitis activity score
OT  - Five factor scores
OT  - Polyarteritis nodosa
OT  - Relapse
EDAT- 2017/03/28 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/03/26 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/03/16 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/03/26 06:00 [entrez]
AID - 10.1007/s00296-017-3706-5 [pii]
AID - 10.1007/s00296-017-3706-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2017 May;37(5):685-694. doi: 10.1007/s00296-017-3706-5. Epub 2017 
      Mar 24.