PMID- 28342333
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20200106
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 69
IP  - 3
DP  - 2017 Jun
TI  - Evidence for the involvement of heme oxygenase-1 in the antidepressant-like 
      effect of zinc.
PG  - 497-503
LID - S1734-1140(16)30137-2 [pii]
LID - 10.1016/j.pharep.2017.01.010 [doi]
AB  - BACKGROUND: Considering that heme oxygenase-1 (HO-1) and the brain-derived 
      neurotrophic factor (BDNF)-mediated pathway are involved in the pathophysiology 
      of depression and that zinc has been shown to exert beneficial effects in the 
      management of depression, this study investigated the influence of these targets 
      on the antidepressant-like effect of zinc. METHODS: Mice were treated with 
      sub-effective or effective doses of zinc chloride (ZnCl(2), 10mg/kg, po), and 
      45min later, they received intracerebroventricular (icv) injections of 
      sub-effective doses of either zinc protoporphyrin IX (ZnPP, 10mug/mouse, HO-1 
      inhibitor), cobalt protoporphyrin IX (CoPP, 0.01mug/mouse, HO-1 inducer) or K-252a 
      (1mug/mouse, TrkB receptor antagonist). Immobility time and locomotor activity 
      were evaluated through the tail suspension test (TST) and open-field test (OFT), 
      respectively. HO-1 immunocontents were evaluated in the prefrontal cortex and 
      hippocampus 60min after ZnCl(2) (10mg/kg, po) treatment. RESULTS: The 
      antidepressant-like effect of ZnCl(2) was prevented by the treatment with ZnPP 
      and K-252a. Furthermore, sub-effective doses of CoPP and ZnCl(2) produced a 
      synergistic antidepressant-like effect in the TST. None of the treatments altered 
      locomotor activity. ZnCl(2) administration increased HO-1 immunocontents only in 
      the prefrontal cortex. CONCLUSIONS: The results indicate that the 
      antidepressant-like effect of ZnCl(2) in the TST may depend on the induction of 
      HO-1, and activation of TrkB receptor.
CI  - Copyright (c) 2017 Institute of Pharmacology, Polish Academy of Sciences. Published 
      by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
FAU - Manosso, Luana M
AU  - Manosso LM
AD  - Department of Biochemistry, Center of Biological Sciences, Universidade Federal 
      de Santa Catarina, Florianopolis, Brazil.
FAU - Moretti, Morgana
AU  - Moretti M
AD  - Department of Biochemistry, Center of Biological Sciences, Universidade Federal 
      de Santa Catarina, Florianopolis, Brazil.
FAU - Rosa, Julia M
AU  - Rosa JM
AD  - Department of Biochemistry, Center of Biological Sciences, Universidade Federal 
      de Santa Catarina, Florianopolis, Brazil.
FAU - Cunha, Mauricio P
AU  - Cunha MP
AD  - Department of Biochemistry, Center of Biological Sciences, Universidade Federal 
      de Santa Catarina, Florianopolis, Brazil.
FAU - Rodrigues, Ana Lucia S
AU  - Rodrigues ALS
AD  - Department of Biochemistry, Center of Biological Sciences, Universidade Federal 
      de Santa Catarina, Florianopolis, Brazil. Electronic address: alsrodri@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170122
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Chlorides)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Protoporphyrins)
RN  - 0 (Zinc Compounds)
RN  - 15442-64-5 (zinc protoporphyrin)
RN  - 63AAN3JDZE (cobaltiprotoporphyrin)
RN  - 86Q357L16B (zinc chloride)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carbazoles/pharmacology
MH  - Chlorides/administration & dosage/*pharmacology
MH  - Depression/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heme Oxygenase-1/*metabolism
MH  - Hindlimb Suspension
MH  - Hippocampus/drug effects/metabolism
MH  - Indole Alkaloids/pharmacology
MH  - Injections, Intraventricular
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Protoporphyrins/pharmacology
MH  - Zinc Compounds/administration & dosage/*pharmacology
OTO - NOTNLM
OT  - Antidepressant
OT  - Brain-derived neurotrophic factor
OT  - Heme oxygenase-1
OT  - Tail suspension test
OT  - Zinc
EDAT- 2017/03/28 06:00
MHDA- 2017/11/08 06:00
CRDT- 2017/03/26 06:00
PHST- 2016/09/01 00:00 [received]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/03/26 06:00 [entrez]
AID - S1734-1140(16)30137-2 [pii]
AID - 10.1016/j.pharep.2017.01.010 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2017 Jun;69(3):497-503. doi: 10.1016/j.pharep.2017.01.010. Epub 
      2017 Jan 22.