PMID- 28342945 OWN - NLM STAT- MEDLINE DCOM- 20180402 LR - 20180816 IS - 1878-4216 (Electronic) IS - 0278-5846 (Linking) VI - 76 DP - 2017 Jun 2 TI - Cognitive impairment in first-episode drug-naive patients with schizophrenia: Relationships with serum concentrations of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. PG - 163-168 LID - S0278-5846(16)30408-0 [pii] LID - 10.1016/j.pnpbp.2017.03.013 [doi] AB - OBJECTIVES: Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naive (FEDN) patients with schizophrenia. METHODS: The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test. RESULTS: Patients performed significantly worse than controls in nearly all neurocognitive performances except the forward subscale part of the DST. BDNF levels were inversely correlated to TMT-part B scores and positively correlated to VFT-action in the FEDN group. GDNF levels showed a positive correlation with VFT-action scores and a negative correlation with TMT-part B scores of these patients. CONCLUSION: Current data suggests that cognitive dysfunction widely exists in the early stages of schizophrenia. BDNF and GDNF may be jointly contributed to the pathological mechanisms involved in cognitive impairment in FEDN patients with schizophrenia. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Xiao, Wenhuan AU - Xiao W AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Ye, Fei AU - Ye F AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Liu, Chunlai AU - Liu C AD - Department of Psychiatry, Affiliated Kangren Hospital, Ili Kazak Autonomous Prefecture of Xinjiang 835000, PR China. FAU - Tang, Xiaowei AU - Tang X AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Li, Jin AU - Li J AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Dong, Hui AU - Dong H AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Sha, Weiwei AU - Sha W AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. FAU - Zhang, Xiaobin AU - Zhang X AD - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China. Electronic address: zhangxiaobim@163.com. LA - eng PT - Journal Article DEP - 20170322 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (GDNF protein, human) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognitive Dysfunction/*blood/etiology/*physiopathology MH - Female MH - Glial Cell Line-Derived Neurotrophic Factor/*blood MH - Humans MH - Male MH - Schizophrenia/*blood/complications MH - Young Adult OTO - NOTNLM OT - Brain-derived neurotrophic factor OT - Cognitive functions OT - Glial cell line-derived neurotrophic factor OT - Neurotrophins OT - Schizophrenia EDAT- 2017/03/28 06:00 MHDA- 2018/04/03 06:00 CRDT- 2017/03/27 06:00 PHST- 2016/11/28 00:00 [received] PHST- 2017/02/25 00:00 [revised] PHST- 2017/03/19 00:00 [accepted] PHST- 2017/03/28 06:00 [pubmed] PHST- 2018/04/03 06:00 [medline] PHST- 2017/03/27 06:00 [entrez] AID - S0278-5846(16)30408-0 [pii] AID - 10.1016/j.pnpbp.2017.03.013 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:163-168. doi: 10.1016/j.pnpbp.2017.03.013. Epub 2017 Mar 22.