PMID- 28342972
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20211204
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 141
DP  - 2017 May
TI  - Remodeling the Th1 polarized systemic environment contributes to neurogenesis and 
      cognitive function via the Wnt7a pathway in neonatal mice.
PG  - 60-71
LID - S1074-7427(17)30034-5 [pii]
LID - 10.1016/j.nlm.2017.03.002 [doi]
AB  - Neonatal Bacillus Calmette-Guerin (BCG) vaccination results in a positive effect 
      on hippocampal neurogenesis and cognition. Serum cytokines are considered to be 
      the chief culprit. In this study, serum from BCG-treated mice was identified as 
      Th1 polarized serum. The serum showed an increased ratio of IFN-gamma to IL-4 and 
      decreased levels of TNF-alpha and IL-6. After Th1 polarized serum was injected 
      intraperitoneally into postnatal mice, the levels of cytokines and ratio of IFN-gamma 
      to IL-4 in the serum and hippocampus of postnatal mice showed a similar 
      alteration as those in Th1 polarized serum. This result indicated that the immune 
      homeostatic milieu in postnatal mice was broken and the Th1 polarized systemic 
      environment in the BCG-serum group was remodeled. The BCG-serum group displayed 
      more BrdU(+)/DCX(+) cells, BrdU(+)/NeuN(+) cells, Nestin(+) cells and better 
      cognitive abilities. In neural stem cells, the Wnt7a/beta-catenin signaling pathway 
      was activated and exposure to the Wnt7a antagonist Dickkopf-1 inhibited 
      BCG-serum-induced Wnt7a/beta-catenin signaling, neurogenesis and cognitive function. 
      Additionally, BCG-serum was associated with elevations in hippocampal 
      brain-derived neurotrophic factor (BDNF) levels, and BDNF expression in the 
      BCG-serum group was offset by Dickkopf-1 treatment. By rebalancing the Th1 
      polarized systemic environment in neonatal mice, it is possible that treatment 
      with BCG-serum promotes hippocampal neurogenesis and improves cognitive 
      functions, which are associated with Wnt7a/beta-catenin-BDNF signaling.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Xu, YunLong
AU  - Xu Y
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China; South China Research Center for 
      Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, 
      Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
FAU - He, Fen
AU  - He F
AD  - Department of Radiation Oncology, First Affiliated Hospital, Guangzhou Medical 
      University, Guangzhou 510080, PR China.
FAU - Qi, FangFang
AU  - Qi F
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China.
FAU - Yang, Guangqi
AU  - Yang G
AD  - Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, 
      Guangzhou 510080, PR China.
FAU - Zheng, FuXiang
AU  - Zheng F
AD  - Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China.
FAU - Yang, JunHua
AU  - Yang J
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China.
FAU - Wang, Xiao
AU  - Wang X
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China.
FAU - Liu, JunXiu
AU  - Liu J
AD  - Department of Gynecology and Obstetrics, The First Affiliated Hospital of Sun 
      Yat-Sun University, Guangzhou 510080, PR China. Electronic address: 
      liujunxiu99@163.com.
FAU - Zou, JunTao
AU  - Zou J
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou 510080, PR China; Guangdong Province Key Laboratory of 
      Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, 
      #74 Zhongshan 2nd Road, Guangzhou 510080, PR China. Electronic address: 
      zoujunt@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170322
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Dkk1 protein, mouse)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*physiology
MH  - Doublecortin Protein
MH  - Hippocampus/drug effects/*metabolism
MH  - Intercellular Signaling Peptides and Proteins/pharmacology
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Neural Stem Cells/physiology
MH  - Neurogenesis/*physiology
MH  - Spatial Memory/physiology
MH  - Th1 Cells/*physiology
MH  - Wnt Signaling Pathway/*physiology
OTO - NOTNLM
OT  - BCG-serum
OT  - Cognitive function
OT  - Cytokine
OT  - Neurogenesis
OT  - T helper 1
OT  - Wnt7a signaling pathway
EDAT- 2017/03/28 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/03/27 06:00
PHST- 2016/04/28 00:00 [received]
PHST- 2017/02/11 00:00 [revised]
PHST- 2017/03/02 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/03/27 06:00 [entrez]
AID - S1074-7427(17)30034-5 [pii]
AID - 10.1016/j.nlm.2017.03.002 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2017 May;141:60-71. doi: 10.1016/j.nlm.2017.03.002. Epub 
      2017 Mar 22.