PMID- 28343035
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20191008
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 105
DP  - 2017 Jul
TI  - Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and 
      Local Lymph Node Assay (LLNA) in mice.
PG  - 99-105
LID - S0278-6915(17)30129-1 [pii]
LID - 10.1016/j.fct.2017.03.034 [doi]
AB  - 4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal 
      beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly 
      MCHM, was inadvertently released into the Elk River, a municipal water source 
      that serves about 300,000 people in the Charleston, WV area, resulting in 
      temporary contamination of 15 percent of the state's tap water and causing 
      significant dermal exposure. The current studies were undertaken to determine 
      whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or 
      sensitization. BALB/c female mice were treated daily for 3 consecutive days by 
      direct epicutaneous application of 25 muL of various concentrations of crude MCHM 
      or MCHM to the dorsum of each ear. A mouse ear-swelling test was used to 
      determine irritancy potential and was undertaken in combination with the 
      standardized Local Lymph Node Assay (LLNA) to determine skin sensitizing 
      potential. MCHM was found to produce skin irritation at concentrations above 20% 
      and did not produce sensitization. Crude MCHM also produced irritation, although 
      weaker, and in addition was found to be a weak to moderate skin sensitizer. The 
      results are discussed in terms of potential human health hazard.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Johnson, Victor J
AU  - Johnson VJ
AD  - Burleson Research Technologies, Inc., Morrisville, NC, USA. Electronic address: 
      vjohnson@brt-labs.com.
FAU - Auerbach, Scott S
AU  - Auerbach SS
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      NIH, Research Triangle Park, NC, USA.
FAU - Luster, Michael I
AU  - Luster MI
AD  - Burleson Research Technologies, Inc., Morrisville, NC, USA.
FAU - Waidyanatha, Suramya
AU  - Waidyanatha S
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      NIH, Research Triangle Park, NC, USA.
FAU - Masten, Scott A
AU  - Masten SA
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      NIH, Research Triangle Park, NC, USA.
FAU - Wolfe, Mary S
AU  - Wolfe MS
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      NIH, Research Triangle Park, NC, USA.
FAU - Burleson, Florence G
AU  - Burleson FG
AD  - Burleson Research Technologies, Inc., Morrisville, NC, USA.
FAU - Burleson, Gary R
AU  - Burleson GR
AD  - Burleson Research Technologies, Inc., Morrisville, NC, USA.
FAU - Germolec, Dori R
AU  - Germolec DR
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      NIH, Research Triangle Park, NC, USA.
LA  - eng
GR  - HHSN273201400017C/ES/NIEHS NIH HHS/United States
GR  - Z99 ES999999/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20170322
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Cyclohexanes)
RN  - 0 (Irritants)
RN  - 0 (Water Pollutants, Chemical)
RN  - 1558K6RHM3 (4-methylcyclohexanemethanol)
SB  - IM
MH  - Animals
MH  - Cyclohexanes/analysis/*toxicity
MH  - Dermatitis, Allergic Contact/*etiology
MH  - Female
MH  - Humans
MH  - Irritants/analysis/*toxicity
MH  - Local Lymph Node Assay
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Skin Irritancy Tests
MH  - Water Pollutants, Chemical/analysis/toxicity
PMC - PMC5594409
MID - NIHMS866580
OTO - NOTNLM
OT  - 4-Methylcyclohexanemethanol
OT  - Allergic contact
OT  - Dermal hypersensitivity
OT  - Dermal irritancy
OT  - Dermatitis (ACD)
OT  - Elk River spill
OT  - Local Lymph Node Assay (LLNA)
COIS- The authors do not have any conflicts of interest to disclose.
EDAT- 2017/03/28 06:00
MHDA- 2017/08/30 06:00
PMCR- 2018/07/01
CRDT- 2017/03/27 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/03/02 00:00 [revised]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/03/27 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S0278-6915(17)30129-1 [pii]
AID - 10.1016/j.fct.2017.03.034 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2017 Jul;105:99-105. doi: 10.1016/j.fct.2017.03.034. Epub 2017 
      Mar 22.