PMID- 2834304
OWN - NLM
STAT- MEDLINE
DCOM- 19880531
LR  - 20161021
IS  - 0392-3525 (Print)
IS  - 0392-3525 (Linking)
VI  - 17
IP  - 4
DP  - 1987
TI  - Solid tumors and enzyme activity in human lymphocytes.
PG  - 295-9
AB  - A study on the enzyme activity of glucose metabolism in the lymphocytes of 
      patients with solid malignant tumors is reported. The results have shown a 30% 
      mean increase of the hexokinase (HK) activity in patients with solid malignant 
      tumors as compared to the mean value observed in a group of healthy subjects. A 
      relationship between level of HK increase and stage of tumor was also observed. 
      The other examined enzyme activities, phosphofructokinase (PFK), pyruvate-kinase 
      (PK), phosphoglycerate-kinase (PGK), phosphoglucoisomerase (PGI), 
      glyceraldehyde-phosphate dehydrogenase (GAPD) glucose-6-phosphate dehydrogenase 
      (G-6PD), 6-phosphogluconate dehydrogenase (6-PGD) and enolase did not show 
      significant changes. It is concluded that even though the use of HK as tumor 
      marker cannot be hypothesized at the present time, a significant relation between 
      an increased activity of this enzyme and presence of the tumor is unquestionable. 
      Therefore, this biochemical effect induced away from the neoplastic tissue 
      deserves further study.
FAU - Giacchi, R
AU  - Giacchi R
AD  - Divisione di Chirurgia Generale, Ospedali Riuniti, Pesaro.
FAU - Sebastiani, M
AU  - Sebastiani M
FAU - Canestrari, F
AU  - Canestrari F
FAU - Di Quirico, M
AU  - Di Quirico M
FAU - Lungarotti, F
AU  - Lungarotti F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ital J Surg Sci
JT  - The Italian journal of surgical sciences
JID - 8213451
RN  - EC 1.1.- (Carbohydrate Dehydrogenases)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
RN  - EC 2.7.- (Phosphotransferases)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - EC 5.3.1.9 (Glucose-6-Phosphate Isomerase)
SB  - IM
MH  - Adenocarcinoma/*enzymology
MH  - Adult
MH  - Aged
MH  - Carbohydrate Dehydrogenases/blood
MH  - Carcinoma, Squamous Cell/enzymology
MH  - Digestive System Neoplasms/*enzymology
MH  - Female
MH  - Glucose-6-Phosphate Isomerase/blood
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/blood
MH  - Humans
MH  - Lung Neoplasms/*enzymology
MH  - Lymphocytes/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/blood
MH  - Phosphotransferases/blood
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Ital J Surg Sci. 1987;17(4):295-9.