PMID- 28343184
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20220311
IS  - 2191-0200 (Electronic)
IS  - 0334-1763 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Jul 26
TI  - Regulatory role of NGFs in neurocognitive functions.
PG  - 649-673
LID - 10.1515/revneuro-2016-0031 [doi]
AB  - Nerve growth factors (NGFs), especially the prototype NGF and brain-derived 
      neurotrophic factor (BDNF), have a diverse array of functions in the central 
      nervous system through their peculiar set of receptors and intricate signaling. 
      They are implicated not only in the development of the nervous system but also in 
      regulation of neurocognitive functions like learning, memory, synaptic 
      transmission, and plasticity. Evidence even suggests their role in continued 
      neurogenesis and experience-dependent neural network remodeling in adult brain. 
      They have also been associated extensively with brain disorders characterized by 
      neurocognitive dysfunction. In the present article, we aimed to make an 
      exhaustive review of literature to get a comprehensive view on the role of NGFs 
      in neurocognitive functions in health and disease. Starting with historical 
      perspective, distribution in adult brain, implied molecular mechanisms, and 
      developmental basis, this article further provides a detailed account of NGFs' 
      role in specified neurocognitive functions. Furthermore, it discusses plausible 
      NGF-based homeostatic and adaptation mechanisms operating in the pathogenesis of 
      neurocognitive disorders and has presents a survey of such disorders. Finally, it 
      elaborates on current evidence and future possibilities in therapeutic 
      applications of NGFs with an emphasis on recent research updates in drug delivery 
      mechanisms. Conclusive remarks of the article make a strong case for plausible 
      role of NGFs in comprehensive regulation of the neurocognitive functions and 
      pathogenesis of related disorders and advocate that future research should be 
      directed to explore use of NGF-based mechanisms in the prevention of implicated 
      diseases as well as to target these molecules pharmacologically.
FAU - Kumar, Ashutosh
AU  - Kumar A
AD  - .
FAU - Pareek, Vikas
AU  - Pareek V
AD  - .
FAU - Faiq, Muneeb A
AU  - Faiq MA
AD  - .
FAU - Kumar, Pavan
AU  - Kumar P
AD  - .
FAU - Raza, Khursheed
AU  - Raza K
AD  - .
FAU - Prasoon, Pranav
AU  - Prasoon P
AD  - .
FAU - Dantham, Subrahamanyam
AU  - Dantham S
AD  - .
FAU - Mochan, Sankat
AU  - Mochan S
AD  - .
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain/growth & development/metabolism/physiology
MH  - *Cognition
MH  - Cognition Disorders/etiology/*metabolism
MH  - Humans
MH  - Nerve Growth Factors/*metabolism
OTO - NOTNLM
OT  - HPA/HPG axis
OT  - nerve growth factors (NGFs)
OT  - neurocognition
OT  - pathogenesis of psychiatric disorders
OT  - stress
EDAT- 2017/03/28 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/03/27 06:00
PHST- 2016/05/12 00:00 [received]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/03/27 06:00 [entrez]
AID - /j/revneuro.ahead-of-print/revneuro-2016-0031/revneuro-2016-0031.xml [pii]
AID - 10.1515/revneuro-2016-0031 [doi]
PST - ppublish
SO  - Rev Neurosci. 2017 Jul 26;28(6):649-673. doi: 10.1515/revneuro-2016-0031.