PMID- 28343294
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20200930
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 62
IP  - 1
DP  - 2017 May
TI  - Neuroprotective Role of Exogenous Brain-Derived Neurotrophic Factor in 
      Hypoxia-Hypoglycemia-Induced Hippocampal Neuron Injury via Regulating Trkb/MiR134 
      Signaling.
PG  - 35-42
LID - 10.1007/s12031-017-0907-z [doi]
AB  - Hypoxic-ischemic brain injury is an important cause of neonatal mortality and 
      morbidity. Brain-derived neurotrophic factor (BDNF) has been reported to play a 
      neuroprotective role in hypoxic-ischemic brain injury; however, the specific 
      effects and mechanism of BDNF on hypoxic-hypoglycemic hippocampal neuron injury 
      remains unknown. The current study investigated the action of BDNF in regulating 
      cerebral hypoxic-ischemic injury by simulating hippocampal neuron ischemia and 
      hypoxia. We found that BDNF, p-Trkb, and miR-134 expression levels decreased, and 
      that exogenous BDNF increased survival and reduced apoptosis in 
      hypoxic-hypoglycemic hippocampal neurons. The results also show that BDNF 
      inhibits MiR-134 expression by activating the TrkB pathway. Transfection with 
      TrkB siRNA and pre-miR-134 abrogated the neuroprotective role of BDNF in 
      hypoxic-hypoglycemic hippocampal neurons. Our results suggest that exogenous BDNF 
      alleviates hypoxic-ischemic brain injury through the Trkb/MiR-134 pathway. These 
      findings may help to identify a potential therapeutic agent for the treatment of 
      hypoxic-ischemic brain injury.
FAU - Huang, Weidong
AU  - Huang W
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China. weidonghuangsx@163.com.
FAU - Meng, Facai
AU  - Meng F
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China.
FAU - Cao, Jie
AU  - Cao J
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China.
FAU - Liu, Xiaobin
AU  - Liu X
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China.
FAU - Li, Min
AU  - Li M
AD  - Department of Neurosurgery, Shaanxi Provincial People's Hospital, NO 256, Youyi 
      West Road, Xi'an, 710068, China.
LA  - eng
PT  - Journal Article
DEP - 20170326
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MIRN134 microRNA, rat)
RN  - 0 (MicroRNAs)
RN  - 0 (Neuroprotective Agents)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Hypoxia
MH  - Cells, Cultured
MH  - Glucose/deficiency
MH  - Hippocampus/cytology/metabolism
MH  - MicroRNAs/*genetics/metabolism
MH  - Neurons/drug effects/*metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxygen/*metabolism
MH  - Rats
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - BDNF
OT  - Hypoxic-ischemic brain injury
OT  - TrkB
OT  - hippocampal neuron
OT  - miR-134
EDAT- 2017/03/28 06:00
MHDA- 2018/03/07 06:00
CRDT- 2017/03/27 06:00
PHST- 2016/11/20 00:00 [received]
PHST- 2017/02/27 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
PHST- 2017/03/27 06:00 [entrez]
AID - 10.1007/s12031-017-0907-z [pii]
AID - 10.1007/s12031-017-0907-z [doi]
PST - ppublish
SO  - J Mol Neurosci. 2017 May;62(1):35-42. doi: 10.1007/s12031-017-0907-z. Epub 2017 
      Mar 26.